lec 3 action2.pptx

lec 3 action2.pptx - Mechanism of Action-2 05 receptor...

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Page 1 receptor turnover, something to keep in mind table: hormone receptors and their effectors from hormones to their actions, 7tmr and single tmr, amplification, crosstalk, diseases signaling through G-protein linked receptor linked to the enzyme AC or the enzyme PLC (seven transmembrane domain receptors) signaling through receptors having or not having intrinsic tyrosine kinase activity, the mitogenic and the cytokine activated pathways (single transmembrane domain receptors) signaling through nitric oxide and receptors linked to the enzyme Guanylate Cyclase sequence of endocrine events involved in the activation of endocrine glands and their targets Mechanism of Action-2 05 THE STORY LINE signal to system endocrine gland hormone secretion H transport H - R interaction target response Today’s lecture
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Page 2 Today’s lecture ± S E sensor integrator center effector afferent “story line” efferent “story line” negative feedback “story line” diagram for a control system as that present in a refrigerator a “reflex arc” a base for a control model S ± E … if story lines are linked through an integrator, then you have “control”…
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Page 3 Today’s lecture “story line” I suggest you put this information into a table YOU design !!! Membrane Hormone Receptors How receptors get to the membrane and what might happen after they bind its ligand
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Page 4 Membrane Hormone Receptors Adenylate cyclase ACTH, ßadrenergic Cas(Gs),LH, HCG, FSH, Glucagon, PGs, PTH, TSH, alpha adrenergic (Gi), SS Guanylate cyclase ANP (ANF) Phoshoinositol turnover and Ca flux Ach receptor (muscarinic), alpha adrenergic Cas, Ang II (also activates Tyr-kinase), GnRH (LHRH), TRH, AVP Receptor protein tyrosine kinase (mitogenic pathway) Insulin, IGF, EGF, CSF, FGF Receptor - associated tyrosine kinase (cytokine pathway) GH, PRL, EPO, Interleukins, NGF, T-cell receptors Ion channels Ach receptor (nicotinic), GABA Membrane receptors and their ligands GPCR to AC GPCR to PLC 7tmr single tmr Membrane Hormone Receptors
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Page 5 plasma memb. COOH 2 ECF ICF seven - transmembrane domain receptors ß - adrenergic and glucagon receptors among many others EGF insulin PDGF ANP GH, Prl, cytokines kinase Cys rich Cys residues JAK2 ECF ICF COOH N H N H2 hydrophobic aa 4 - tm domain receptors are usually ion channels single - tm domain receptors G Membrane Hormone Receptors Membrane Hormone Receptors GPCR to AC An unactivated G-protein coupled receptor. The seven transmembrane alpha helices are connected by three extracellular and three intracellular loops of varying length. The extracellular loops may be glycosylated, and the intracellular loops and C- terminal tail may be phosphorylated. The receptor is coupled to a G-protein consisting of a GDP-binding ± -subunit bound to a ² / ³ component. The ± and ³ subunits are tethered to the membrane by lipid groups.
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lec 3 action2.pptx - Mechanism of Action-2 05 receptor...

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