lec 4 hypothalamus.pptx

lec 4 hypothalamus.pptx - Hypothalamus 06 Introduction to...

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Page 1 Hypothalamus 06 Introduction to communication, “story lines”, “reflex arc” models, neuroendocrinology, hierarchies, integration, endopathologies. Hypothalamic - pituitary axis, neurohypophyseal neuronal pathway, posterior pituitary function. Neurovascular hypothesis, hypothalamic and hypophysiotropic neurohormones to the anterior pituitary, experiments. Harris and portal vessels, Halaz and Hypothalamic Hypophysiotropic Area, neuroendocrine transducer cells and AP function. Assessing in vivo and in vitro hypophysiotropic hormone release. Neuroendocrine control, hierarchies, integrators. Inputs to neuroendocrine transducer cells and their effects on AP hormones. ME as a neuroendocrine integration site, other neuroendocrine integration sites. Today’s lecture “story line” I suggest you put this information into a table YOU design !!!
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Page 2 Today’s lecture The “story line” table Components of a hormone response system. Responses produced by hormones generally are sensed by whatever apparatus activated the secretion and usually decrease further secretion. ± S E sensor integrator center effector afferent “story line” efferent “story line” negative feedback “story line” diagram for a control system as that present in a refrigerator a “reflex arc” a base for a control model S ± E … if story lines are linked through an integrator, then you have “control”…
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Page 3 S ± E S ± E S ± E S ± E Endocrinology main functions and their basic control Introduction to communication S ± E S ± E S ± E S ± E Endocrinology main functions and their basic control Introduction to communication
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Page 4 ( ± ) ± ( ± )1 ( ± )3 S ± E S ± E ( ± )2 e.g. Insulin ( ± 1) Glucagon ( ± 2) Cortisol ( ± 3) Epinephrine SS and GRH GH T3 - T4 others . .. S ± E Blood glucose as example of a multihormonal control Introduction to communication AP hormones are regulated by hierarchical control system with trophic & target hormone (trophic, TSH) (target, T4) thyroid TSH T4 Alteration of trophic vs target hormonal balance S ± E Hierarchy, negative feedback and endocrine pathology Introduction to communication
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Page 5 The Hypothalamic- Pituitary axis Hypothalamus Pituitary Stalk Anterior / Posterior Pit. Hypothalamic Nuclei Vascular link to AP Neuronal link to PP Stalk transection Kidney transplant Neonate pituitary Harris, Halaz, Yalow, Shally, Guilleman (NTC) Neuroendocrine control Mid-sagittal section of the human pituitary gland and adjacent hypothalamic structures. The Hypothalamic- Pituitary Hypothalamus Pituitary Stalk Anterior / Posterior Pit. Hypothalamic Nuclei Vascular link to AP Neuronal link to PP Stalk transection Kidney transplant Neonate pituitary Harris, Halaz, Yalow, Shally, Guilleman (NTC) Neuroendocrine control Mid-sagittal section of the human hypothalamus and pituitary. The principal nuclei of the hypothalamus are listed within the bracket.
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Page 6 The Hypothalamic- Pituitary axis Hypothalamus
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This note was uploaded on 10/19/2011 for the course ENDOCRINOL 450 taught by Professor Advis during the Spring '11 term at Rutgers.

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lec 4 hypothalamus.pptx - Hypothalamus 06 Introduction to...

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