lec 6 pit_pineal.pptx

lec 6 pit_pineal.pptx - Pituitary (AP + PP) and Pineal...

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Page 1 Pituitary (AP + PP) and Pineal Glands 09 Introduction to hypothalamus, pituitary and pineal function. Posterior pituitary hormones (OT, AVP) and their secretion, function and regulation. Countercurrent mechanism and the effect of AVP on collecting ducts. Mechanism of action and control of AVP secretion: osmotic stimulation, baroregulation, additional cellular actions. AVP pathologies: hypothalamic / nephrogenic diabetes insipidus (DI), SIADH, gene mutation in familial DI. Anterior pituitary melanotropic hormones (ßEND, MSH) and their secretion, function and regulation. MSH effects on pigmentation and food intake, species variability, regulation, rhytms, receptors, mechanism of action. ßEND central and peripheral effects, action mechanism. Pineal hormones (melatonin) and their secretion, function and regulation. Melatonin: biosynthesis, N-acetyl transferase activity and rhytms, light - dark cycle, physiological functions, sleep, behavioral rhythmicity, reproduction, thermoregulation. Introduction Hormones and “story lines” Components of a hormone response system. Responses produced by hormones generally are sensed by whatever apparatus activated the secretion and usually decrease further secretion.
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Page 2 Introduction Hormones and “story lines” Components of a hormone response system. Responses produced by hormones generally are sensed by whatever apparatus activated the secretion and usually decrease further secretion. Posterior Pituitary Hormones Hypothalamic connection Oxytocin (OT) Vasopressin (AVP, ADH) AVP, blood pressure and water control PVN, SON, hypophyseal tract Posterior pituitary AVP = ADH OT
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Page 3 Posterior Pituitary Hormones PVN POA ME SON thirst, Na appetite maternal behavior natriuresis / antidiuresis uterine contraction and milk ejection hepatic portal vein osmoreceptors mechanoreceptors in cervix and breast S E ± S ± E Inputs and outputs to hypothalamic integration centers ( ± ) like PVN, SON Hypothalamic connection Oxytocin (OT) Vasopressin (AVP, ADH) AVP, blood pressure and water control S ± E Posterior Pituitary Hormones Peripheral info reaches brain integration centers through nervous system Hypothalamic connection Oxytocin (OT) Vasopressin (AVP, ADH) AVP, blood pressure and water control S ± E
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Page 4 Posterior Pituitary Hormones peripheral afferent information also reaches brain integration centers through the vascular system (e.g. to osmo- receptors) Hypothalamic connection Oxytocin (OT) Vasopressin (AVP, ADH) AVP, blood pressure and water control S ± E Posterior Pituitary Hormones - Gly - Gly His glycoprotein neurophysin II neurophysin I ADH AVP -----> OT -----> 1 - 9 1 - 9 109 - 147 COOH N H 2 105 - 106 - COOH N H 2 - AVP / OT are nonapeptides with disulfide bond between cystine residues 1 - 6. Precursors, encoded by distinct but structurally related genes, are processed on route to PP Hypothalamic connection Oxytocin (OT) Vasopressin (AVP, ADH) AVP, blood pressure and water control S ± E
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Page 5 Posterior Pituitary Hormones
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This note was uploaded on 10/19/2011 for the course ENDOCRINOL 450 taught by Professor Advis during the Spring '11 term at Rutgers.

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lec 6 pit_pineal.pptx - Pituitary (AP + PP) and Pineal...

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