lec 7 calcium.pptx

lec 7 calcium.pptx - Page 1 Ca regulating hormones...

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Unformatted text preview: Page 1 Ca regulating hormones Introduction: effects of Ca / PO4 ions; Parathyroid: anatomy, histology, PTH; Thyroid: anatomy, histology, Calcitonin; Kidney: Vit D. Overview of Ca regulation: bone, kidney, and GI tract as effectors of Ca regulating hormones. PTH: structure, receptor, secretion, effect of Ca / Vit D metabolites / other factors, effects Calcitonin: structure, biological actions, effect on osteoclasts and bone reabsorption Vit D: production and metabolism, absorption, transport and excretion, biological actions Diseases: hypoPTH, low Ca tetany, hyperPTH, kidney stones, rickets, osteoporosis. Case study (e.g. hypocalciuric hypercalcemia) 10 Introduction Hormones and story lines thyroid gland blood Ca PTH Calcitonin Vit.D + + - + kidney parathyroid gland Page 2 Ca Regulating Hormones Introduction Parathyroid Thyroid Vitamin D Bone turnover Pathologies Why do blood Ca and PO4 levels are regulated ??? Ca is required for Na permeability in nerves, Ach release at NMJ, excitation - contraction coupling in muscles, (e.g.. low ECF-Ca and tetany) Ca serves as intracellular signal for some hormones (e.g.. Epinephrine on stroke volume) Ca is needed for some enzymes effect, for the secretion of proteins, for blood clotting to occur (e.g.. EDTA) Ca is a constituent of bone (Ca storage depot) PO4 functions as part of intracellular buffer systems PO4 is an important constituent of macromolecules such as nucleic acids, phospholipids, metabolic intermediates, and phosphoproteins PO4 is a constituent of bone (PO4 storage depot) Ca Regulating Hormones Introduction Parathyroid Thyroid Vitamin D Bone turnover Pathologies Why do blood Ca and PO4 levels are regulated ??? excitable non-excitable VGNaC G q Tyr-K Gs Gi VmCa VGCC SERCa ec fCa entry icf IP3 Ry storage mito metab packaging exocytosis gene express.. cytoskeleton enzymes/R PKC PLC PLD IP3R RyR VGCC TTX - sensitive TTX - non sensitive VGCCs, LVA vs HVA LVA, rapid and voltage inactivation HVA, slow inactivation T-,L-,N-,P-,Q, and R-type of VGCCs diversity due to multiple genes for Ca channel subunits and alternative splicing. The alpha1 subunit has the voltage sensor, gating machinery, and a channel pore. basal pacemaker activity, plasma membrane Ca oscillator, action potentials last longer (50-500 ms) some NPs, Nts and hormones act by modulating spontaneous activity of the pituitary membrane oscillator Ca serves as intracellular signal Page 3 Introduction Parathyroid Thyroid Vitamin D Bone turnover Pathologies What endocrine signals control all these calcium fluxes ???...
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lec 7 calcium.pptx - Page 1 Ca regulating hormones...

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