lec 9 catecholamines.pptx

lec 9 catecholamines.pptx - Catecholamines Introduction to...

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Page 1 Introduction to the adrenal medulla and to the stress response: neural and endocrine components catecholamines: synthesis, secretion, receptors, mechanism of action, general hormonal effects sympathoadrenal roles: intermediary metabolism, thermogenesis, CV, respiratory, link to stress pheochromocytoma as main endocrine pathology: a possible role for medullary peptides Catecholamines 14 Today’s lecture Adrenal medulla and its “story lines”
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Page 2 Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The sympatho-adrenal system as a faster neuronal and a relatively slower endocrine component a “fight or flight” array of responses (also known as the stress response) involve the sympathetic nervous system and the adrenal stimuli: emotional stress, cold, heat, burns, pH changes, exercise, anoxia, asphyxia, hypotension, hypoglycemia responses: increase heart/respiration rate, blood flow to heart, brain, skeletal muscle, liver, glycogenolysis, lipolysis secretion: Epi, cortisol, insulin, ACTH, glucagon, renin, melatonin S ± E Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The sympatho-adrenal system as a faster neuronal and a relatively slower endocrine component S ± E The hormonal element The chromaffin cell The neuronal elements
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Page 3 Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The sympatho-adrenal system as a faster neuronal and a relatively slower endocrine component The hormonal element The chromaffin cell The neuronal elements S ± E Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction Both sympathetic and parasympathetic branches of the ANS are involved in the stress response The hormonal element The chromaffin cell The neuronal elements S ± E
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Page 4 Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The hormonal element The chromaffin cell The neuronal elements Both sympathetic and parasympathetic branches of the ANS are involved in the stress response S ± E Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction Both sympathetic and parasympathetic branches of the ANS are involved in the stress response S ± E The hormonal element The chromaffin cell The neuronal elements
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Page 5 Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The main integrator of the sympatho-adrenal system is located in the hypothalamus (PVN) The hormonal element The chromaffin cell The neuronal elements PVN NTS AP DMN ARC DMH VMH A ( Neuronal = N Blood-born - BB ) ME N BB PBN S ± E Adrenal medulla Catechol- amines Sympatho- adrenal effects Pathologies Introduction The main integrator of the sympatho-adrenal system is located in the hypothalamus (PVN) S ± E
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Page 6 Adrenal medulla Catechol- amines Sympatho-
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lec 9 catecholamines.pptx - Catecholamines Introduction to...

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