lec 12 glucocorticoids.pptx

lec 12 glucocorticoids.pptx - Page 1 Introduction to...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Page 1 Introduction to steroids in general: synthesis, regulation, mechanisms of action, development, physiology and related - diseases Adrenal gland: anatomy, histology, hormones, effects, feedback. cortisol secretion, receptors, mechanism of action and effects Cortisol: effects on glucose metabolism, anti-inflamatory action, regulation, synthetic cortisol, the stress response Cortisol related pathologies: Addison's disease and Cushing's syndrome Glucocorticoids 21 HPA axis Introduction HPA axis and its story lines Page 2 Steroids Adrenal Cortisol Pathologies Steroid pathway and enzymes Adrenal and gonadal steroids have cholesterol as their common origin 3BD I 21BHL 11BHL 18hydrxylase 18dehydrogen... 17alpha hydroxylase 17alph a desmolase 3BDI 21BHL 11BHL androstenedione 3BDI hydroxysteroid dehydrogenase aromatase aldosterone cortisol testosterone estradiol mineralocorticoid pathway glucocorticoid pathway estrogen / androgen pathway pregnenolone progesterone 11-deoxycorti... corticosterone 18-hydroxycorti... 17 a-hydroxypreg... 17 a-progesterone 11 - deoxycortisol mevalonic acid AcCoA SCCE HMG-CoA reductase VLDL DHEA cholesterol pyruvate (*) metyperone test (*) Steroids Adrenal Cortisol Pathologies Adrenal and gonadal steroids have cholesterol as their common origin mineralocorticoid glucocorticoid gonadal steroids Steroid pathway and enzymes 3BD I 21BHL 11BHL 18hydrxylase 18dehydrogen. . 17alpha hydroxylase 17alph a desmolase 3BDI 21BHL 11BHL androstenedione 3BDI hydroxysteroid dehydrogenase aromatase aldosterone cortisol testosterone estradiol mineralocorticoid pathway glucocorticoid pathway estrogen / androgen pathway pregnenolone progesterone 11-deoxycorti. . corticosterone 18-hydroxycorti. . 17 a-hydroxypreg. 17 a-progesterone 11 - deoxycortisol mevalonic acid AcCoA SCCE HMG-CoA reductase VLDL DHEA cholesterol pyruvate (*) metyperone test (* Page 3 Steroids Adrenal Cortisol Pathologies ACTH, AgII and LH stimulate SCCE or desmolase, a rate-limiting enzyme for steroidogenesis Steroid pathway and enzymes SCCE cP450 glucocorticoids mineralocorticoids androgens 3BD I 21BHL 11BHL 18hydrxylase 18dehydrogen. . 17alpha hydroxylase 17alph a desmolase 3BDI 21BHL 11BHL androstenedione 3BDI hydroxysteroid dehydrogenase aromatase aldosterone cortisol testosterone estradiol mineralocorticoid pathway glucocorticoid pathway estrogen / androgen pathway pregnenolone progesterone 11-deoxycorti. . corticosterone 18-hydroxycorti. . 17 a-hydroxypreg. 17 a-progesterone 11 - deoxycortisol mevalonic acid AcCoA SCCE HMG-CoA reductase VLDL DHEA cholesterol pyruvate (*) metyperone test (* Steroids Adrenal Cortisol Pathologies primary (A) and secondary (B, C) regulation sites for steroid biosynthesis Steroid pathway and enzymes 3BD I 21BHL 11BHL 18hydrxylase 18dehydrogen. ....
View Full Document

Page1 / 27

lec 12 glucocorticoids.pptx - Page 1 Introduction to...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online