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lec 14 mineralocorticoids

lec 14 mineralocorticoids - Mineralocorticoids Introduction...

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Page 1 Mineralocorticoids 24 Nephron H2O, ADH, CD glucose, PCT, Tm JGA, renin, Ag II, vasoconstriction, thirst, aldosterone, kinins, vasodilation, Na, ZG, DCT, ANP, BNP, CNP endothelin, adrenomedullin Introduction concepts to remember: a) water, glucose, mineral metabolism; b) adrenal in stress and blood pressure Renin - angiotensin (RAS) and kallikrein - kinin (KKS) systems: synthesis, secretion receptors, mechanism of action, effects Mineralocorticoids: aldosterone synthesis, secretion, receptors, mechanism of action, hormonal effects Peptide hormones and paracrine factors: ANP, BNP, CNP, ET, adrenomedullin Integration: response to hemorrage and to dehydration Pathophysiology: RAS & KKS involvement in hypertension and in hyperaldosteronism Introduction aldosterone and its “story lines” ALDO renin Ag II
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