lec 16 sexdiffpuberty.pptx

lec 16 sexdiffpuberty.pptx - Sex differentiation to puberty...

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Page 1 Sex differentiation to puberty Sexual differentiation in general: chromosomal, gonadal and phenotypic sex, endocrine control of phenotypic differentiation, role of testicular hormones in male development, disorders of sexual differentiation Hypothalamic sexual differentiation: sexual dimorphic areas, androgenized female model, olfactory placode and GnRH migration, development and maturation of female HPG axis as intro to puberty and to adult cyclicity Puberty: definition, hypothesis, role of GnRH and other systems, diseases 30 Introduction repro and its “story lines” &
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Page 2 Introduction genetic sex established at conception governs development of gonadal sex Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset egg sperm genetic sex gonadal sex phenotypic sex internal urogenital system external features CNS external genitalia secondary sex charachteristics FSH-LH secretion sex behavior S ± E Introduction The undifferentiated state has a bipotential gonad and both Mullerian and Wolffian systems Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset S ± E
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Page 3 S ± E Introduction The bipotential gonad can give origin to an ovary (cortex, default) or to a testis (medulla) Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset S ± E Introduction Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset The bipotential gonad can give origin to an ovary (cortex, default) or to a testis (medulla)
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Page 4 S ± E Sex and Gonadal Differentiation undifferent gonad cortex --> ovary medulla --> testis female pattern is default unless testis-determining factor (TDF), a transcription factor of the SRY gene (sex-determining region of Y gene), is present Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset The bipotential gonad can give origin to an ovary (cortex, default) or to a testis (medulla) S ± E Sex and Gonadal Differentiation Sex differentiation general aspects Hypothalamic sex differentiation Neuroendo control of Puberty Onset Development of the testes and ovaries from common precursors in the genital ridges. SRY, (the sex-determining region of the Y chromosome), is the gene expressed only in cells that develop into Sertoli cells. In the absence of SRY these cells develop into follicle cells. Sertoli cells express SOX 9 and other transcription factors and the autocrine factor FGF9 (fibroblast growth factor 9) that lead to differentiation and multiplication of Sertoli cells. Enclosure of the primordial germ cells by Sertoli cells to form the primitive spermatic cords and unequivocal recognition of the primitive gonads as testes occurs as early as the seventh week. Subsequent recruitment of mesenchymal cells and
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This note was uploaded on 10/19/2011 for the course ENDOCRINOL 450 taught by Professor Advis during the Spring '11 term at Rutgers.

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lec 16 sexdiffpuberty.pptx - Sex differentiation to puberty...

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