lec 17 cycle.pptx - Reproductive Cyclicity Male repro: a...

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Page 1 Reproductive Cyclicity 31 Male repro: a simpler way of control Menstrual cycles: ovary / uterine anatomy and cell types, follicular phase, ovulation, luteal phase, cyclicity Race events: removal of P4 negative feedback, follicular recruitment or FSH inducing its own receptors, pulsatile LH secretion a richer communication language, preovulatory E2 triggering the LH preovulatory surge GnRH network as basic model for cyclicity Contraception, pathology Introduction repro and its “story lines”
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Page 2 Male repro is not a cyclic event In male E2 do not induce a preovulatory LH surge, but POA electrical stimulation does Reproduction Menstrual cycle Race events GnRH system Contraception Pathology Male repro is not a cyclic event In male E2 do not induce a preovulatory LH surge, but POA electrical stimulation does Reproduction Menstrual cycle Race events GnRH system Contraception Pathology
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Page 3 Male repro is not a cyclic event In male E2 do not induce a preovulatory LH surge, but POA electrical stimulation does Reproduction Menstrual cycle Race events GnRH system Contraception Pathology Actions of FSH and LH on the testis. FSH acts directly only on Sertoli cells, whereas LH acts directly solely on Leydig cells. Paracrine cross-talk mediated by growth factors likely takes place between Sertoli and Leydig cells and between Sertoli cells and germ cells, and possibly between peritubular myoid cells and both Leydig and Sertoli cells. cAMP = cyclic adenosine monophosphate; PKA = protein kinase A; CREB = cyclic AMP response element binding protein; StAR = steroid acute regulatory protein; P450c17 = 17 ± hydroxylase/lyase; AR = androgen receptor; AMH = antimüllerian hormone; ABP = androgen binding protein. Male repro is not a cyclic event In male E2 do not induce a preovulatory LH surge, but POA electrical stimulation does Reproduction Menstrual cycle Race events GnRH system Contraception Pathology The formation of male mammalian germ cells. Each primary spermatogonium ultimately gives rise to 64 sperm cells. Cytokinesis is incomplete in all but the earliest spermatogonial divisions, resulting in expanding clones of germ cells that remain joined by intercellular bridges. Maturing spermatids are closely associated with and enfolded by the Sertoli cells.
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Page 4 Male repro is not a cyclic event Reproduction Menstrual cycle Race events GnRH system Contraception Pathology Schematic structure of the androgen receptor and of the mechanism of androgen action Male repro is not a cyclic event In male E2 do not induce a preovulatory LH surge, but POA electrical stimulation does Reproduction Menstrual cycle Race events GnRH system Contraception Pathology
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Page 5 Male repro is not a cyclic event Reproduction Menstrual cycle Race events GnRH system Contraception Pathology Male repro is not a cyclic event
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This note was uploaded on 10/19/2011 for the course ENDOCRINOL 450 taught by Professor Advis during the Spring '11 term at Rutgers.

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lec 17 cycle.pptx - Reproductive Cyclicity Male repro: a...

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