lec 18 intake.pptx

lec 18 intake.pptx - Ingestive Behaviors 33 (a review of...

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Page 1 Ingestive Behaviors 33 A neuroendocrine control system: components, a reflex arc, the endocrine system, the ANS, endocrine / nervous systems as afferents and efferents, the theoretical comparator or integrator unit, membrane potential, transcription factors and integrators, crosstalk at a subcellular level as a regulatory control paradigm Elements involved in the neuroendocrine control of food intake, the hypothalamic PVN, ME and POA as integration centers, discussion of other integrated neuroendocrine systems (stress and temperature regulation linked to stress and food intake) and of obesity and anorexia Neuroendocrine control as a story of circles, intersecting circles, intersecting circles, intersecting . .. S ± E (a review of general endocrinology) Introduction control and “story lines” Integration (or the basic “reflex arc” model) ± S E sensor integrator center effector afferent “story line” efferent “story line” negative feedback “story line” basic diagram for a control system as that present in a refrigerator
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Page 2 Physiological Endocrinology A “basic reflex arc” model has orga- nization levels, structure / function, control Neuroendocrine control Food intake, bulimia, anorexia Circles within circles … The endocrine system is a communication system involved in homeostatic control of life. It acts through its hormones which control four main basic processes Reproduction Growth and development Maintenance of internal environment Energy production, utilization and storage S ± E Physiological Endocrinology The “basic reflex arc” model is based on the neuronal components of a reflex arc Neuroendocrine control Food intake, bulimia, anorexia Circles within circles … S ± E
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Theoretical control elements Refrigerators are regulated with similar components to that of an endocrine sytem Neuroendocrine control Food intake, bulimia, anorexia Circles within circles … variable under control (t°C / °F) thermostat (set point) t°C / °F detector (feedback) comparator common language error signal (on/off) engine (amplifier) TARGET FINAL ENDOCRINE EFFECT N T C hypothalamus long loop negative feedback short and ultrashort negative feedbacks hierarchies: gonadal adrenal thyroid others A P set point S ± E Negative feedback is control The “basic reflex arc” model is shown by the various endocrine hierarchies Neuroendocrine control Food intake, bulimia, anorexia Circles within circles … E2 P4 receptor Cortisol. receptor C S comp . CRH AP adrenal cortisol T3 receptor N TC gonadal hierarchy adrenal hierarchy thyroid hierarchy C S comp . GnRH
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lec 18 intake.pptx - Ingestive Behaviors 33 (a review of...

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