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lec 3 homeostasis - 03 Homeostasis The goal of this lecture...

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6/11/11 1 Homeostasis Basic concepts Homeostasis Signal transduction 03 The goal of this lecture is to discuss the concept of homeostasis and to introduce basic signal transduction mechanisms involved in homeostatic regulation The sections for this lecture are: Life is a series of chemical reactions occurring in compartmentalized environments. The main purpose of life is to keep itself alive Physiology, the study of how life works, is based on the simultaneous occurrence of the following three concepts: levels of organization structure / function relationship homeostatic regulation How do we know what we know reductionism, the most successful experimental approach in physiology life as chemical reactions occurring under linear versus non-linear conditions integrative physiology and non-linear conditions functional genomics, the future of experimental physiology Structure / function relationship and levels of organization Basic concepts life is a series of chemical reactions occurring in compartmentalized environments
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6/11/11 2 communication at cellular and sub-cellular levels neural communication endocrine communication neuroendocrine communication signal transduction pathways cross-talk among signal transduction pathways channels and enzymes as fi nal effectors homeostasis and the concept of feedback regulation Basic concepts the main purpose of life is to keep itself alive life runs against a thermodynamic equilibrium energy is used to generate work to keep life alive the need of potential energy stores due to sporadic input theoretical components of a feedback loop (“refrigerator”) visualization of a classic motor re fl ex arc as feedback the body thermoregulatory control as example homeostatic processes related to thermoregulation Feedback regulation life runs against a thermodynamic equilibrium A B C
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