6/11/111Homeostasis•Basic concepts •Homeostasis •Signal transduction03 The goal of this lecture is to discuss theconcept of homeostasis and to introducebasic signal transduction mechanismsinvolved in homeostatic regulationThe sections for this lecture are:Life is a series of chemical reactions occurring in compartmentalized environments. The main purpose of life is to keep itself alivePhysiology, the study of how life works, is based on the simultaneous occurrence of the following three concepts:levels of organizationstructure / function relationshiphomeostatic regulation•How do we know what we know–reductionism, the most successful experimental approach in physiology–life as chemical reactions occurring under linear versus non-linear conditions–integrative physiology and non-linear conditions–functional genomics, the future of experimental physiology•Structure / function relationship and levels of organizationBasic conceptslife is a series of chemical reactions occurring in compartmentalized environments
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6/11/112•communication at cellular and sub-cellular levels–neural communication–endocrine communication–neuroendocrine communication–signal transduction pathways–cross-talk among signal transduction pathways–channels and enzymes as final effectors•homeostasis and the concept of feedback regulationBasic conceptsthe main purpose of life is to keep itself alive•life runs against a thermodynamic equilibrium •energy is used to generate work to keep life alive•the need of potential energy stores due to sporadic input•theoretical components of a feedback loop (“refrigerator”)•visualization of a classic motor reflex arc as feedback•the body thermoregulatory control as example•homeostatic processes related to thermoregulationFeedback regulationlife runs against a thermodynamic equilibriumABC