lec 16 metabolism.pptx

lec 16 metabolism.pptx - Metabolism The goal of this...

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1 Metabolism 22 The goal of this lectures is to discuss basic physiology associated with the control of metabolism, such as the neuroendocrine control of pre- and post- absorptive states. The sections for this lecture are: Introduction Neuroendocrine control of metabolism Insulin and Glucagon Growth hormone(GH) and growth factors (IGF) Thyroid hormones (tri / tetra iodotyronin,T3 and T4) Catecholamines (Cas, Epi and Norepinephrine) Glucocorticoids (Cortisol in humans) Major metabolic pathways of the absorptive state Major metabolic pathways of the post - absorptive state Life is a series of chemical reactions occurring in compartmentalized environments. The main purpose of life is to keep itself alive Physiology, the study of how life works, is based on the simultaneous occurrence of the following three concepts: levels of organization structure / function relationship homeostatic regulation Introduction central integration center negative feedback signal afferent efferent receptor effector S ± E the endocrine system plays a predominant role in the neuroendocrine control of metabolism
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2 FUEL METABOLISM IN ANABOLIC / CATABOLIC PHASES State Hormones Fuel Source Process anabolism Insulin Glucagon diet Glycogen synthesis Triglyceride synthesis Protein synthesis catabolism Insulin Glucagon storage depots Glycogenolysis Lipolysis Proteolysis Ketogenesis Introduction Introduction
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3 glycogen G - 1 - P G - 6 - P F - 6 - P F - 1,6 -diP triose pyruvate amino acids Krebs cycle proteins fats glucose glycogen phosphorilase glycogen synthetase hexokinase G-6-Pase F-1,6-diPase transaminases glucose insulin glucagon epinephrin cortisol acetyl CoA PFK Introduction Introduction Absortive State
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4 Introduction Post - Absortive State Introduction
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5 Introduction Introduction
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6 Introduction The main endocrine systems involved in the neuroendocrine control of metabolism are Introduction
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7 Insulin Insulin 51 aa, 2 chains, 3 disul f de bonds, C-peptide stimulates anabolism and favors energy storage increases glycogen storage and inhibits both glycogen breakdown and gluconeogenesis increases fatty acid synthesis and decreases lipolysis and ketogenesis stimulates transport of glucose and of some aminoacids into striated muscle / adipose tissue increases protein synthesis in liver, muscle, adipose like growth factors, has a growth promoting effect
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8 Insulin kinase Cys rich ECF ICF NH2 COOH ± ² memb Tyr-P of docking protein IRS - 1 SH2- domain mediated complex formation Ser - Thr kinase cascade DNA synthesis and gene transcription SOS ras raf MEKK MAPK p90rsk PP1G glycogen synthase stimulation of glucose transport phosphatidyl inositol -3 -P insulin hydrophobic aa Insulin
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9 kinase Cys rich ECF ICF NH2 COOH ± ² memb insulin hydrophobic aa Insulin Insulin CHIEF
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This note was uploaded on 10/19/2011 for the course ANIMALSCIE 11 06 300 taught by Professor Advis during the Spring '11 term at Rutgers.

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lec 16 metabolism.pptx - Metabolism The goal of this...

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