lec 18 reprodution1.pptx

lec 18 reprodution1.pptx - 6/11/11 Reproduction The goal of...

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6/11/11 1 Reproduction 25 The goal of these lectures is to discuss basic physiology associated with the control of reproduction (from sexual diferentiation to adult reproductive function). The sections for this lecture are: Introduction Sexual differentiation Development of a control system Overview, male/female reproduction Life is a series of chemical reactions occurring in compartmentalized environments. The main purpose of life is to keep itself alive Physiology, the study of how life works, is based on the simultaneous occurrence of the following three concepts: levels of organization structure / function relationship homeostatic regulation male female ? Introduction
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6/11/11 2 Introduction events in sexual differentiation (develoment of chromosomal sex, gonadal sex, phenotypic sex) endocrine control of phenotypic differentiation, role of testicular hormones in male development disorders of sexual differentiation (disorders of chromosomal sex, gonadal sex, phenotypic sex) hypothalamic sexual differentiation, sexual dimorphic areas and the androgenized female model the olfactory placode as the origin of the GnRH neuronal system and its migration to the ME development / maturation of the female HPG axis as an introduction to puberty and to adult cyclicity Sexual differentiation Overview
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6/11/11 3 external features CNS external genitalia 2 sex char. FSH-LH secretion sex beh. Sexual differentiation egg sperm genetic sex gonadal sex phenotypic sex internal urogenital system genetic sex established at conception governs development of gonadal sex, and this in turn regulates development of phenotypic sex in the undifferentiated gonad cortex --> ovary medulla --> testis female pattern is default unless testis-determining factor (TDF), a transduction factor of SRY gene (sex-determining region of Y gene), is present Y X X X XY XX testis ovary male female
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lec 18 reprodution1.pptx - 6/11/11 Reproduction The goal of...

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