Case 4 - PHRX 4041 Biologic Response Modifiers Trinh Pham...

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PHRX 4041 Biologic Response Modifiers Trinh Pham, Associate Clinical Professor Case 1: Mrs. Johnson is about to start Interleukin 2 (IL-2) therapy for her metastatic melanoma. IL-2 at a dose of 72,000 IU/kg every 12 hours for 8 doses PMH: Hypertension Meds: Captopril 5 mg every day The order includes: Discontinue antihypertensive medication Obtain daily weights, ins and outs, blood pressure and O2 saturation status, Scr, LFTs and bilirubin Acetaminophen 500 mg every 6 hour around the clock Naproxen 250 mg every 12 hours Nausea and Vomiting: Ondansetron 8 mg IV every 12 hours Prochlorperazine 10 mg IV every 6 hours prn nausea and vomiting Antibiotic Prophylaxis: Cefazolin 1 gm IV every 8 hours What is the reason for Mrs. Johnson to receive scheduled acetaminophen and naproxen at the same time? Why shouldn’t a steroid be prescribed to control nausea and vomiting?
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Why is it necessary to prescribe cefazolin when IL-2 is an immune stimulating agent? What other PRN medications should be prescribed to manage other side effects?
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This note was uploaded on 10/08/2011 for the course PHAR 4030 taught by Professor Dr.miller during the Spring '11 term at UConn.

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Case 4 - PHRX 4041 Biologic Response Modifiers Trinh Pham...

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