111003%20Antipsychotics%202%20per%20page

111003%20Antipsychotics%202%20per%20page - 10/1/11 Todays...

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10/1/11 1 Additional Readings Topics Reading Antipsychotic Drugs Foye’s Chapter 22, pages 601 – 615 PHRx 4040 Drug Design: Antipsychotic Drugs October 3, 2011 Dr. Marcy J. Balunas
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10/1/11 2 Antipsychotic Drugs Covered Traditional Antipsychotics Chlorpromazine Perphenazine Haloperidol Atypical Antipsychotics Clozapine Olanzapine Quetiapine Risperidone Ziprasidone Iloperidone Paliperidone Aripiprazole Lurasidone Asenapine Phenothiazine Class of Traditional Antipsychotics Phenothiazine first synthesized in 1883 No antipsychotic activity Antipsychotic activity discovered from activities looking for new antihistamines
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10/1/11 3 Development of Phenothiazine Antipsychotics Hypothesized that antagonists of histamine exist o Tried various compounds known to work on ANS o Started wit benzodioxanes and made numerous molecular modifications o Benzodioxanes led to development of ethers of ethanolamine o Ethanolamines led to diphenhydramine and ethylenediamines which further led to development of
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This note was uploaded on 10/08/2011 for the course PHAR 4030 taught by Professor Dr.miller during the Spring '11 term at UConn.

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111003%20Antipsychotics%202%20per%20page - 10/1/11 Todays...

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