Anxiety%20Slides%20Prt%202%20-%204pp

Anxiety%20Slides%20Prt%202%20-%204pp - Rating Scales...

Info iconThis preview shows pages 1–4. Sign up to view the full content.

View Full Document Right Arrow Icon
Treatment Expectations Rating Scales Hamilton Anxiety Rating Scale (HAM–A) •Anxious mood •Tension •Fears •Cognition •Depressed mood •Insomnia •Musculo-sensory sxs •Cardiovascular, respiratory, GI, GU, & autonomic; behavior during interview Psychic Somatic 0 5 10 15 20 25 30 Base Week 1 Week 2 Week 4 Week 6 Week 8 Week 12 GAD Response To Sertraline Sertraline Placebo Allgulander C, et al. Am J Psychiatry 2004;161:1642–9. • End of week #1 10% reduction • End of week #4 30% reduction • End of week #12, 55% reduction GAD Response To Venlafaxine & Buspirone 0 5 10 15 20 25 30 Base Week 1 Week 2 Week 3 Week 4 Week 6 Week 8 Venla 150 Busp 30 Davidson JRT, et al. J Clin Psychiatry 1999;60:528–35. • End of week #1 20% reduction • End of week #4 40% reduction
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
0 5 10 15 20 25 30 Base Week 1 Week 2 Week 4 GAD Response To Bzdps Alprazolam Diazepam Elie R, Lamontagne Y. J Clin Psychopharmacology 1984;4:125–9. • End of week #1 40–50% reduction • End of week #4 60–70% reduction Drug–Target Genomics 5HT1A receptor polymorphisms •HRT1A C(–1019)G has been associated with amygdala reactivity and “trait” anxiety Polymorphisms of proteins which deactivate G proteins coupled to receptors (RGS2) •Possibly associated with anxiety traits Val66Met polymorphism of BDNF •Risk for mood and anxiety phenotypes Case #2 (See Handout) What are the important issues in this case ?
Background image of page 2
Important Case Findings Current Symptoms: anxious; recurrent thoughts about perfection/order, contamination; repetitive images; repetitive checking; avoidant behavior. Symptoms present over time; functioning impaired Pt reports tension headaches everyday Psychosocial stressors: none reported No treatment hx No substance abuse (+) FH; (+) tob, (–) caffeine Meds: ibuprofen 200 mg bid–tid Genetics: CYP2D6 *1/*2ax2 (gene duplication) What anxiety disorder does this patient likely have ? Diagnostic Criteria
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 4
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/08/2011 for the course PHAR 4030 taught by Professor Dr.miller during the Spring '11 term at UConn.

Page1 / 12

Anxiety%20Slides%20Prt%202%20-%204pp - Rating Scales...

This preview shows document pages 1 - 4. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online