Anxiety%20Slides%20-%209.19%20-%204pp

Anxiety%20Slides%20-%209.19%20-%204pp - Pharmacotherapy All...

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W HICH P HARMACOTHERAPY ? Pharmacotherapy All of the following may be started as monotherapy for GAD tx SSRIs SNRIs Benzodiazepines Buspirone Treatment expectations are not identical Understanding the rate and extent to which symptoms improve is important GAD OCD PD PTSD PMDD SAD Fluoxetine (Prozac) X X X Sertraline (Zoloft) X X X X X Paroxetine (Paxil) X X X X X X Fluvoxamine (Luvox) X X Citalopram (Celexa) Escitalopram (Lexapro) X Venlafaxine (Effexor) X X X Duloxetine (Cymbalta) X FDA Approved Anxiety Disorder Indications (SSRIs/SNRIs) GAD = generalized anxiety disorder; OCD = obsessive compulsive disorder; PD = panic disorder; PTSD = post- traumatic stress disorder; PMDD = pre-menstrual dysphoric disorder; SAD = social anxiety disorder. GAD OCD PD PTSD PMDD SAD Fluoxetine (Prozac) X X X Sertraline (Zoloft) X X X X X Paroxetine (Paxil) X X X X X X Fluvoxamine (Luvox) X X Citalopram (Celexa) Escitalopram (Lexapro) X Venlafaxine (Effexor) X X X Duloxetine (Cymbalta) X FDA Approved Anxiety Disorder Indications (SSRIs/SNRIs) GAD = generalized anxiety disorder; OCD = obsessive compulsive disorder; PD = panic disorder; PTSD = post- traumatic stress disorder; PMDD = pre-menstrual dysphoric disorder; SAD = social anxiety disorder.
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Clinical Pharmacology SSRIs, SNRIs, Bzdps Duloxetine Escitalopram Imipramine Paroxetine Venlafaxine Buspirone Alprazolam Clonazepam Diazepam Lorazepam GENERIC BRAND START INCR. BY TARGET RANGE DTI MAX LOWER FLUVOXAMINE LUVOX 12.5–25 qd/bid 12.5–25 qd/bid 100–200 0.125 300 POTENCY SERTRALINE ZOLOFT 12.5–25 qd/bid 12.5–25 qd/bid 100–200 0.125 200 FLUOXETINE PROZAC 10–20 10–20 20–60 0.5 80 HIGHER PAROXETINE PAXIL 10–20 10–20 20–50 0.5 60 POTENCY CITALOPRAM CELEXA 10–20 10–20 20–40 0.5 60 ESCITALOPRAM LEXAPRO 5–10 5–10 10–20 0.5 30 D OSING G UIDE : SSRI S IN A NXIETY D ISORDERS • Fluvoxamine/sertraline typically need longer durations to titrate to effective dose; doses < 100 mg/day more likely to be ineffective • Fluoxetine, citalopram, paroxetine, escitalopram typically need shorter durations to effective dose; doses >
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This note was uploaded on 10/08/2011 for the course PHAR 4030 taught by Professor Dr.miller during the Spring '11 term at UConn.

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Anxiety%20Slides%20-%209.19%20-%204pp - Pharmacotherapy All...

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