8 - BIO 317: Lecture 8! Prof. William Collins! Ofce: 534...

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Prof. William Collins OfFce: 534 Life Sciences Building OfFce Hours: Tuesdays, 11:30 AM - 12:30 PM or by appointment Recommended Reading: BIO 317: Lecture 8
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Desensitization of the Acetylcholine Receptor When two ACh molecules bind to the α subunits in the receptor, the molecule undergoes a conformational change and the pore opens ACh stays bound for only about 0.5 - 1 ms and then comes off receptor ACh is rapidly hydrolyzed by acetylcholinesterase (AChE) If the ACh levels remain elevated for 20 ms or longer, the channel enters a third conformational state and becomes inactivated. Normally AChE limits the duration of the post synaptic potential.
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Comparison Between NMJ and CNS Synapses Property NMJ CNS Synaptic Ratio pre : post 1 : 1 10,000 : 1 Release Sites per Synapse > 100 1 - 2 Vesicles Released per AP > 100 1 - 2 Post Synaptic Potential (psp) Excitatory suprathreshold Excitatory or Inhibitory subthreshold
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CNS Fast Synaptic Transmission Excitatory Synaptic Transmission – Neurotransmitter binds to receptors in postsynaptic membrane – Cation channel in receptors opens – Postsynaptic cell depolarizes (subthreshold)
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This note was uploaded on 10/05/2011 for the course BIO 317 taught by Professor Simonhalegoua during the Spring '08 term at SUNY Stony Brook.

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8 - BIO 317: Lecture 8! Prof. William Collins! Ofce: 534...

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