Chapter_9b_Oxidative_phosphorylation

Chapter_9b_Oxidative_phosphorylation - Oxidative...

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Oxidative phosphorylation: Extraction of energy from NADH and FADH 2 ADP is phosphorylated to ATP as electron carriers ( NADH and FADH 2 ) are reoxidized in the presence of O 2 . Two complicated processes: 1. Respiratory chain ( electron transport ) On the inner mitochondrial membrane 4 protein complexes: I, II, III, IV Cytochrome c Ubiquinone (Q)—a lipid 2. Chemiosmosis Why so complicated? Why so many steps? Answer: A single step would release too much free energy all at once, which could not be harvested by the cell.
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NADH + H + and FADH 2 from glycolysis, pyruvate oxidation, and the citric acid cycle are oxidized by the respiratory chain, regenerating NAD + and FAD. Most of the enzymes and other electron carriers of the chain are part of the inner mitochondrial membrane. O 2 is the final acceptor of electrons and protons, forming H 2 O. Energetics of the respiratory chain Complex I (26) Complex III (10) Complex IV (8)
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Electron transport and proton pumping
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Electron transport and proton pumping
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The proton-motive force The chemiosmotic mechanism couples proton transport to oxidative phosphorylation. As the electrons move along the respiratory chain, they lose energy, captured by proton pumps that actively transport H
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This note was uploaded on 10/09/2011 for the course LS 2 taught by Professor Pires during the Spring '08 term at UCLA.

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Chapter_9b_Oxidative_phosphorylation - Oxidative...

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