Understanding Biochemical Science Articles 9-21

Understanding Biochemical Science Articles 9-21 -...

Info iconThis preview shows pages 1–2. Sign up to view the full content.

View Full Document Right Arrow Icon
Biochemistry is a scientific field that concentrates on understanding and discovering how different reactions between molecules and atoms affect biological life. Thus, the articles that are published rely heavily on the IMRAD format in order to maintain a consistent layout. This layout is necessary in the scientific field, so scientist can analyze and replicate the results of the experiment. One article, “Physical Trapping of HIV-1 Synaptic Complex by Different Structural Classes of Integrase Strand Transfer Inhibitors” by Krishan Pandey, et al., is published in the American Chemical Society website. This article is mainly an observational experiment trying to determine the effectiveness of inhibitors at suppressing HIV-1 virus from infecting other cells. The second article is called, “Allogeneic Human Mesenchymal Stem Cells Restore Epithelial Protein Permeability in Cultured Human Alveolar type II cells by Secretion of Angiopoietin-1” by Xiaohui Fang, et al., and is published in JBC papers. Xiaohui’s article is trying to study human Mesenchymal stem cells (MSC), where he debates that MSC is able to treat acute lung injury. Both articles target audiences are fellow biochemists and are published for purely informational purposes. In the next few paragraphs, a comparison between these two papers will be discussed and the IMRAD format these papers were written in, to further understand the biochemistry discipline. These two articles are trying to explore a cure, or at least suppress an illness, by using biochemistry procedures. Pandey’s paper is an experiment done in vitro , and in vivo , in order to determine which inhibitors are effective at suppressing different HIV-1 viral strands. The inhibitors are chemical molecules, and they are able to modify integrase viral DNA interactions from the host cell. By modifying the integrase, the inhibitors will physically trap the synaptic complex, preventing DNA binding, which leads to HIV virus spreading to other host cells. On the other hand, Fang’s article is also able to experiment with MSC in vivo , and in vitro . MSC are adult stem cells capable of differentiating into other cells and secrete soluble compounds. MSC is able to restore epithelial permeability to proteins across polarized human alveolar epithelial type II cells caused by an acute lung injury. By restoring permeability, the fluids won’t get build up in the lungs, which normally results in 40% death rate. A co-culture of MSC and type II cell epithelial revealed that angiopoietin-1 (Ang1) was secreted from MSC and is responsible for restoring permeability. Both of these articles have similar purposes and formats, but their topics
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 2
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/10/2011 for the course ENGLISH ENG 333 taught by Professor Frazen during the Fall '10 term at N.C. State.

Page1 / 4

Understanding Biochemical Science Articles 9-21 -...

This preview shows document pages 1 - 2. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online