1-Synthesis-action%20bioregulators[1]

1-Synthesis-action%20bioregulators[1] - 10/5/2009 1...

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Unformatted text preview: 10/5/2009 1 Synthesis, Metabolism, and Synthesis, Metabolism, and Actions of Bioregulators Actions of Bioregulators I. Amino acids, Amines, I. Amino acids, Amines, Peptides, and Proteins Peptides, and Proteins 10/5/2009 2 Major types Major types Catecholamines • Catecholamines • Indoleamines • Peptides/proteins Catecholamines Catecholamines catechol 10/5/2009 3 Catecholamines Catecholamines Dopamine norepinephrine & epinephrine are • Dopamine, norepinephrine & epinephrine are neurotransmitters as well as (neuro)hormones • Peripheral catecholamines are metabolized by liver monoamine oxidase Indoleamines Indoleamines 10/5/2009 4 Indoleamines Indoleamines Serotonine or 5 hydroxytryptamine is a • Serotonine or 5-hydroxytryptamine is a neurotransmitter • Melatonin is a pineal neurohormone, secreted primarily in the dark and important in the regulation of biorhythms Peptide hormones Peptide hormones 10/5/2009 5 Peptide hormones Peptide hormones • Gene transcription in nucleus Gene transcription in nucleus • Translation of mRNA to preprohormone on ribosomes in rough endoplasmic reticulum (RER) • Signal peptide attaches to RER membrane, prohormone is packaged into vesicles • Vesicles translocate to Golgi apparatus followed by formation of storage granules • Additional processing of prohormone occurs in...
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1-Synthesis-action%20bioregulators[1] - 10/5/2009 1...

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