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Unformatted text preview: Grouping by making multiple enzyme complexes is much more efficient Don’t need to know details of reactions*** Hydroxyethyl-TTP on the first enzyme Lipoamide- has long arm structure, which interacts to make acetyl group, makes amide linkages to side chain PHD complex Boyerbiochem.com click on interactive animations Regulation of the PHD Complex Under high energy level situations the enzyme, E1, is inhibited by NADH and acetyl CoA The enzyme, E1, is also modulated by phosphorylation and dephosphorylation (hormonally controlled) Fumarase- adds water across the double bonds Malate dehydrogenase- strips off hydrogen’s and left with starting compound Siccinyl-CoA and citrate can say stop here after acetyl-CoA. And other steps can give feedback inhibition. Linear verses Circular Paths Additions of component substrates to linear pathways give a stiochiometric increase in products Addition of component substrates to circular pathways can have very non-linear effects. Why?...
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- Spring '07
- Cellular Respiration, Adenosine triphosphate