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11 - CHAPTER 17 LIPID METABOLISM PART 2 Metabolism of fatty...

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4/12/11 C HAPTER 17 L IPID M ETABOLISM P ART 2 Metabolism of fatty acids and lipids part 2 Biosynthesis of fatty acids Metabolism of the ketone bodies Cholesterol Energy from fatty acids Each round of beta-oxidation yields about 17 ATP Biosynthesis of fatty acids Food is not our only source of fat All organisms can synthesize fatty acids for long term energy storage and use in membrane structures In humans Acetyl CoA is converted to fatty acid esters Synthesis of fatty acids is similar to degradation Differences between fatty acids synthesis and degradation Synthesis occurs in cytoplasm Degradation occurs in mitochondria Acyl carrier protein is used during synthesis as the point of attachment All synthesis occurs in a multienzyme complex -fatty acid synthase ACP looks very similar to Coenzyme A *Growing fatty acids tail grows on end of chain at the sulfydryl group of the ACP.
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