Roth+Drug+Delivery+Spec+Topics+092410

Roth+Drug+Delivery+Spec+Topics+092410 - DRUG DELIVERY...

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DRUG DELIVERY 125:201:Introduction to BME Professor Charles M. Roth Fall 2010
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OUTLINE Introduction to me Conventional drug delivery Whole body pharmacokinetics Tissue level drug transport Cellular level transport Nanoparticle delivery systems Liposomes Case studies Doxil Abraxane Gene silencing research in the Roth lab
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BIO CHARLES ROTH BSE, Chemical Engineering, U. Penn., 1989 PhD, Chemical Engineering, U. Delaware, 1994 Postdoc, Bioengineering, Massachusetts General Hospital, 1995-97 Instructor in Surgery and Bioengineering, Harvard Medical School, 1997-2000 Rutgers 2000-present; Joint CBE/BME Research: Nanobiotechnology; gene silencing with an emphasis on cancer Major leadership roles in BME: BME Honors Academy, founding Director, 2002-2006 Undergraduate Director, 2006-2008 REU in Cellular Bioengineering 2010-present
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PHARMACEUTICALS (DRUGS) Preventive medicine (e.g., Lipitor) Therapeutics Minor indications (ibuprofen for headache) Major indications (taxol for cancer) Casual Caffeine (tablet form = NoDoz) Nicotine Cigarette as a drug delivery device (pulmonary delivery) Nicotine patch (transdermal drug delivery) Viagra/Cialis et al.
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U.S. PHARMA MARKET www.pharmalot.com/wp-content/uploads/2008/03/. ..
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Tablets/Capsules http://www.avmed.com/ima ges/c_rx-capsule.jpg Injectables http://www.indiamart. com/cscpharma/gifs/in jectable.jpg Inhalants http://www.bath.ac.uk/ pr/releases/images/vect ura-inhale.gif http://www.life- tech.com/pm/nb1app3.jpg Transdermal products and implants Skin Drug PHARMACEUTICAL DOSAGE FORMS
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GUT/LIVER PASSAGE http://www.doctorfungus.org/thedrugs/images/antifung_1.jpg
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ROUTE OF ADMINISTRATION AND PK Different routes affect the way in which the body acts on the drug, and hence its concentration-time profile in bloodstream and tissues this is pharmacokinetics Drug effectiveness is dictated by a combination of pharmacokinetics and pharmacodynamics how the drug affects the body W.M. Saltzman, Drug Delivery , Oxford Press, 2001
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LEVOFLOXACIN PROFILE http://www.drugs.com/pro/levaquin.html
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ONE-COMPARTMENT MODEL
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THEOPHYLLINE 500 mg bolus i.v. injection into 70 kg patient
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TWO-COMPARTMENT MODEL Plasma and tissues
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PBPK MODELS Physiologically-based pharmacokinetic (PBPK) model Each tissue is divided into vascular and interstitial spaces Baxter et al., Cancer Res., 54:1517 (1994).
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CONTROLLING PK One can modify a drug to alter its PK properties E.g., PEGylation (can be done to both small molecule drugs as well as antibodies and other biologicals) Alternatively, one can develop a drug delivery system (DDS) Liposomes Hydrogels Particulate systems Stimuli-responsive materials
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MATERIALS FOR DRUG DELIVERY -- CHEMISTRY Compatibility with the therapeutic agent Solubility Non-reactive Biocompatibility – shouldn’t cause toxicity or other adverse responses Cytotoxicity of carrier Cytotoxicity of DDS Accumulation Immune response
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This note was uploaded on 10/11/2011 for the course BIOMEDICAL 201 taught by Professor Berth during the Fall '10 term at Rutgers.

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Roth+Drug+Delivery+Spec+Topics+092410 - DRUG DELIVERY...

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