17- innate immune - 1 Lecture Notes: Immune System (Part I:...

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1 Lecture Notes: Immune System (Part I: Innate Immune System) I. Parts of the Immune System A. Innate or Nonspecific system 1. External body membranes like skin and mucosae i. prevents physical entry of microorganisms ii. first line of defense 2. Phagocytes, antimicrobial proteins, inflammation i. activated by chemical signals when external defenses are penetrated ii. Second line of defense B. Adaptive or Specific system 1. Main components are the B and T lymphocytes i. B-lymphocytes involved in humoral or antibody-mediated immunity ii. T-lymphocytes involved in cellular or cell-mediated immunity 2. Takes considerable time but is highly specific i. this is the body’s third line of defense C. Functional System 1. has organs that are involved in the immune response but involves trillions of individual immune cells 2. the immune system confers immunity which is resistance to disease II. Innate defenses A. Function 1. combat pathogens which are harmful or disease-causing microorganisms 2. in a state of readiness and responds to protect the body from ALL foreign substances starting within minutes of invasion. B. Surface Barriers 1. Skin i. heavily keratinized epithelial membrane is a physical barrier ii. resistant to most weak acids, weak bases, bacterial enzymes and toxins. iii. secretions are acidic (pH 3-5) and inhibit bacterial growth iv. sebum contains chemicals that are toxic to bacteria 2. Mucous membranes i. line all body cavities that open to the exterior including the digestive, respiratory, urinary, and reproductive tracts. ii. stomach secretes HCl and protein-digesting enzymes which kill microorganisms. iii. Saliva and lacrimal fluid contains lysozyme, an enzyme that destroys bacteria. iv. Sticky mucus traps microorganism that enter the digestive and respiratory passageways. v. structure modifications such as the tiny mucus-coated hairs and ciliated mucosa of the respiratory tract which trap and sweep particles away from lower respiratory passages. 3.
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This note was uploaded on 10/19/2011 for the course PCB 3703C taught by Professor Asd during the Spring '09 term at University of Central Florida.

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17- innate immune - 1 Lecture Notes: Immune System (Part I:...

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