The Citric Acid Cycle - in the presence of NAD + . Combines...

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The Citric Acid Cycle/ The Krebs Cycle (2) pyruvate enters mitochondrial matrix. CO 2 given off as COO - group is removed; forms acetate. Acetate is oxidized by pyruvate dehydrogenase in the presence of NAD + ; NAD + is reduced to NADH. One H + and CO 2 are produced. Coenzyme A is attached to acetate forming acetyl CoA . 1. Acetyl CoA is combined with oxaloacetate (plus one H 2 O) by citrate synthase and forms citrate . Gives of CoA-SH. 2. Citrate is converted to Isocitrate by the enzyme Aconitase and the removal and addition of one H 2 O. 3. Isocitrate is decarboxylated and oxidized by isocitrate dehydrogenase producing α- ketoglutarate . NAD + is reduced to NADH. One CO 2 and H + are produced. 4. α-ketoglutarate is decarboyxlated by α-ketoglutarate dehydrogenase
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Unformatted text preview: in the presence of NAD + . Combines succinyl and CoA into succinyl-CoA . NAD + reduced to NADH. 1 CO 2 and H + produced. 5. Succinyl-CoA is phosphorylated by Succinyl-CoA synthetase , releasing the CoA group and forming 1 ATP and succinate . 6. Succinate is oxidized by succinate dehydrogenase and 2 H + + 2 e-are used to reduce FAD + to FADH 2 . Fumarate is produced. 7. Fumarate is hydrated by fumarase to form malate . 8. Malate is oxidized by malate dehydrogenase in the presence of NAD + producing NADH and oxaloacetate . One H + produced. TOTAL PRODUCTS (1 molecule of glucose = 2 turns of cycle) 6 NADH 2 FADH 2 2 ATP...
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