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Presentations - Single Molecular Force Spectroscopy-Study...

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Single Molecular Force Spectroscopy Single Molecular Force Spectroscopy ------Study the mechanical properties and conformations of individual molecules Qiang Fu Nov 25 th , 2002
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Outline Outline Single Molecular Force Spectroscopy Experimental Techniques Polymers Proteins Conclusions Single Covalent Bond
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Motivations Mechanical forces are very important for the function biological organism. DNA transcriptions, Protein Folding, etc. The properties of such system are difficult to study in macroscopic level. Impossible to isolate the information of single molecule from the measurements ensembles.
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F Fixture Scale Force Post How to measure Mechanical Properties? How to measure Mechanical Properties?
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Typical Forces and length scales in single Typical Forces and length scales in single molecule levels molecule levels Curr. Opin. Chem. Bio. 2000, 4: 524-530
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Atomic Force Microscopy Optical Tweezers Magnetic Force Micro-needles Experiment Techniques Force sensitivity ~pN Displacement ~nm Immobilization
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Stretching Individual Molecules Stretching Individual Molecules Microscopes Force
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Presentations - Single Molecular Force Spectroscopy-Study...

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