BIOL300%20Lecture%205%20S.H.

BIOL300%20Lecture%205%20S.H. - COURSE EVALUATIONS LET YOUR...

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C OURSE E VALUATIONS L ET YOUR VOICE BE HEARD ! You can: help instructors improve future course offerings inform decision-makers for merit, promotion, tenure, and teaching awards Thank you for participating in this important process . Prof. Morton J. Mendelson Deputy Provost (Student Life and Learning)
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C OURSE E VALUATIONS MAKE A D IFFERENCE Easy to complete: Takes only 5-10 minutes The system is open 24/7 Available from now on Access : 1. Log in to your MINERVA account 2. A pop-up window will direct you to the course evaluations Alternate way to access the course evaluations: a. Select Student Menu b. Click on Mercury Online Course Evaluation Menu c. Then on Submit your course evaluations d. Click on the Course link Address any questions/comments to: MINERVA Help Line
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Lecture 5 G protein-coupled receptor signaling II Reading for Lectures 4 - 5: Lodish Ch. 15, pp. 635-660
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Termination of response 1) Affinity of receptor for ligand decreases when GDP of G α is replaced with GTP 2) G α -GTP is quickly hydrolyzed 3) cAMP phosphodiesterase hydrolyzes cAMP to AMP
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Termination of response: Desensitization 5) There are also kinases that phosphorylate only one type of ligand-activated GPCR (homologous desensitization) Dephosphorylation by constitutive phosphatases resensitizes
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BIOL300%20Lecture%205%20S.H. - COURSE EVALUATIONS LET YOUR...

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