BIOL300%20Lecture%206%20S.H.

BIOL300%20Lecture%206%20S.H. - Ca2 can be used as 2nd...

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Ca 2+ can be used as 2nd messenger, because [Ca 2+ ] is kept very low in cytosol by pumps in the ER and plasma membrane
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Ca 2+ is a ubiquitous intracellular messenger! Not only GPCRs, but also other receptors, or sperm entry can trigger a rise in intracellular Ca 2+ Intracellular Ca 2+ after fertilization Ca 2+ triggers development, muscle contraction, secretion, including neurotransmitters
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--Complex positive and negative feedback by Ca 2+ results in Ca 2+ spikes or oscillations; the more ligand, the closer these spikes are spaced. --Calcium events also have complex spatial organization
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16_27_Ca_calmodulin.jpg Many Ca 2+ effects are mediated by calmodulin, which changes its conformation upon cooperative binding of 4 Ca 2+ Ca 2+ /calmodulin binds to and activates for example Ca 2+ pumps that pump Ca 2+ out of the cell and Ca 2+ /calmodulin- dependent kinase II (CaM-kinase II)
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a memory device (short-term) Catalytic domain is masked by
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This note was uploaded on 10/12/2011 for the course BIOL 300 taught by Professor Nilson during the Spring '11 term at McGill.

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BIOL300%20Lecture%206%20S.H. - Ca2 can be used as 2nd...

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