BIOL300%20Lecture%209%20S0.H.-1

BIOL300%20Lecture%209%20S0.H.-1 - Cytokine Receptors...

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Integrins can directly activate the MAPK cascade. When integrins bind ECM proteins, Focal adhesion kinase (FAK) is recruited to FAs FAK phosphorylates itself, which recruits Src tyrosine kinase further phosphorylating FAK One pY on FAK recruits the adaptor Grb2 starting the Ras/Raf cascade Juliano RL (2002) Annu Rev Pharmacol Toxicol 42, 283 Integrin cytoplasmic tail has no kinase activity
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Alternatively, integrins can upregulate RTK signaling: causes binding of integrin to RTKs resulting in stronger RTK activation Integrin-mediated adhesion (integrin aggregation and integrin binding to ECM):
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Unformatted text preview: Cytokine Receptors Erythropoietin induces red blood cell proliferation and differentiation Other examples of cytokines: prolactin, interleukins, inteferons Activation is identical to RTKs except: ligand monomer binds receptor dimer; the kinase (JAK) is a separate protein JAKs cross-phosphorylate each other Dimerization exposes NLS STAT bound to activated cytokine receptor is phosphorylated by JAK SHP1-/- mice die because of excess blood cell production Short-term Heterozygous mutation here might make you exceptional! Signal termination Long-term...
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This note was uploaded on 10/12/2011 for the course BIOL 300 taught by Professor Nilson during the Spring '11 term at McGill.

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BIOL300%20Lecture%209%20S0.H.-1 - Cytokine Receptors...

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