Lecture 5 - RNA structure and function

Lecture 5 - RNA structure and function - Structure of RNA...

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Structure of RNA RNA is a polymer of ribonucleoside 5’-monophosphates
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Types and Cellular Location of RNA 1.The cytosol contains a set of RNA molecules which interact in protein synthesis. Ribosomal RNA (rRNA)-is the most abundant. Transfer RNA (tRNA)-one or more exists for each amino acid. Messenger RNA (mRNA)-although the least abundant is specific for each protein. Heterogeneous (hnRNA)-precursor to mRNA Small Nuclear RNA (snRNA). Involved in splicing, chromatin structure. 2.Mitochondria contain a unique set of the same types of RNA. Proteins are synthesized in mitochondria as well as in cytosol. 3.The nucleus is the site of RNA synthesis and contains precursors of cytoplasmic RNA as well as nuclear-specific RNA. An important part of the nuclear-specific RNA is the small nuclear RNA (snRNA) which is required for the formation of mature mRNA. 4.rRNA and tRNA are relatively stable, whereas mRNA often has a short half-life.
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Size and Distribution of Selected Cellular RNA Species Number of Relative RNA Class MW Nucleotides Percent Ribosomal RNA - 80 - 85 28S 1.7 x 106 5400 18S 0.65 x 106 2100 5.8S 5 x 104 160 5S 3.9 x 104 120 Transfer RNA - 10 - 12 4S 2.5 x l04 65 - 110 Messenger RNA0.1 - 1.5 x 106 300 -4300 1 - 5 Nuclear RNA - - 2 - 10 ______________________________________________________________________ ______
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Helical structure of RNA involves intramolecular base pairing
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Double-helical stem-loop regions in RNA often form “hairpins”
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RNA molecules have tertiary structures
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tRNA has two roles: activating amino acids and recognizing codons in mRNA Transfer RNA (tRNA) is the adapter molecule for protein synthesis.
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Lecture 5 - RNA structure and function - Structure of RNA...

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