Lecture 14; 9-23 - Example 1: Sugar and Transcriptional...

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Example 1: Sugar and Transcriptional Regulation: The lac Operon (Devlin: section 8.2, 8.3) The lac operon is an example of prokaryotic transcriptional regulation. Operon - A region of DNA that contains a single promoter that is responsible for the regulation of several genes through the synthesis of a single mRNA. These are found only in prokaryotic cells and permit coordinate regulation of metabolic pathways.
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There are 4 genes that permit E. coli to grow on lactose: lacI gene - a regulatory protein, a repressor of lacZ, lacY and lacA gene transcription. lacZ gene- β -galactosidase lacY gene - lactose transporter lacA gene- an acetylates toxic galactosides Both lactose and cAMP regulate lac expression
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Lac Control The E. coli lac operon was the first fully analyzed genetic element with regard to its repressed and induced states. The genes encoded by the lac operon are expressed at low or undetectable levels in the presence of glucose (even if lactose is present). If glucose is removed and lactose is present, the lac
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Lecture 14; 9-23 - Example 1: Sugar and Transcriptional...

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