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PCB 3063 Exam 1 Fall 2011 Wayne

PCB 3063 Exam 1 Fall 2011 Wayne - 1 Please briefly but...

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Unformatted text preview: 1- Please briefly but completely define the following terms and give an example of each /a/ modifier (5 pts) - anle [AL-“0k Hon, no pkbfl’h‘pc a; It: com 5001:? biker: prede+ can agra’r ‘lht Scprcss‘wn 0r exprcwaa a; (310% Gilda. ExW3k :3 33:? soCP)Su(3-)=wilé+npc [DUF’T‘ ' alga/it?) SLKH'I': mutant: 7- a hd’Hst’S not “9‘79““ ‘ Wmatid (a drawing might help here; 5 pts) 0‘! n *- __ Whiflarwar: k Jn “flirt ckmmosanc 70 ’fl't 1"” ‘44:“; '4.) ‘I’ZJO 51.54:,- ckronaficl) pres “WA [com arena 01% 3. szch re (5 pt) . kk {3 C1 _ I e o s ‘ 41‘s cpl-J2 (A ”Mg. is ”flu Camden ~17: Lek-ck ‘ch spin“: 4990’“ M 012% W ‘Hm at} or? papkctse J‘fiae Himalaclwc 35 0~ 00mph)“ 5“ 505'“ it, ) Can'tmmerc but 933' The (fitmmm. (:18, my arml‘l’ixz WM ‘57 » at, /d4plosufticient (5 pts) om} One, allele flee“ 333 A 33. (Sanka-Ar 14.... you. {All Scc Hm (ink, 01M: Mam , - fleterogametic sex (5 pts) TLJG JL¥M+ 31m okramosanég 14;" 9&5:ch a has an X out Y 8ch Ckfor'iosorneb‘ 3 +0 Sec (Md-RM; Pkmotapf. For BKGmPlc liars; pile/loam (€99,410: all the Male human 2/ Please list two mitotic checkpoints. You don't need to define or explain them (6 pts). 0 ’3 OWL‘S 43 53C “1? DNA it: ink-6“" + evmg'l‘h‘mfl 600540863 _~_l_____ athHx rrpln'ccxh‘m M Wheat-‘3' nah: Sm: (@pk’mp 3N4 um Macc 60mg”; F6434}. VLEIfi-l X} tomcat. URI: hit-05h lmd‘oefix [$13, ckgmqlih Pat—2.38 Prowl?) _ 1W1”? CWW MOW} 915398 i‘mfi' --—-...______ y 0M; WW is Leia? 3’sz a}??? 50 mm“ chiflifia (~1- Vmbabiw mag has X 9’ (9» 2‘) Feb mg " l ’P m Poems X5 (357:) .ecall the case of recessive epistasis in mice, such that Afl_ B_ are agouti, , bb are black, and aa _ are albino- Answer the following questions in light of this iformati'on. (Hint: drawing a Punnett square might be a good Start.) ' ‘ a. In the cross Aa Bb x Aa Bb, what is the probability that from a litter of seven mice, you see exactly 4 albino animals and 3 non-albino animals (lie. agouti or black)? 6 pts b. Suppose I tell you that Matthew has conducted hundreds of such crosses between double heterozygote parents. His data look like this: 451 albino animals and 549 non- albinos. Now, design and execute a statistical test of the null hypothesis of recessive epistasis. Do you reject your null hypothesis or fail to reject it? Why? 15 pts aaafiflbino 4, 3‘ = agony-H 14.’ Lb: Hack 5) 14th Jr AA 312 rim “Um == Ill/[6 -"-‘ 3/9" 7! P: 4-13}!(1’4“)873/‘93 :. $09734); 35(74)“{3¢)’=35(55L6)(ga Piaosv: 5.370 ‘ fixedly {a ‘HIP {massive efr‘slm‘s 0P nILI‘aS‘sm) we 311W”, €4'plc‘i’ ,4“, - 15"“? ’/!+ at fiepmjeny 40 Le 4mm ml 34 49 lg misty. 40M: loco @rpec’real = V‘f (/0007: 350 «Mao >nafly/Mefl‘s 5) aa____ 7— ifs] 3/4 (I000) = 750 norm/Lina 1:7 UPS/wage)1 . .5501- 750 1 - {:0 we reject +Ae X 350 f ((—7:er~ 3 m6 ‘L 5” ”’ 3’5'%§// noinifam'eefrwssfve . (Finals. ol¥=2~l:l \/ wlen Izmir .a+X°'+abIe er om ”ea/5‘s, PM“; ii her knowledge of basic, undergraduate genetics, Carol had to answer this - ,n as part of her PhD qualifying exams. So does everyone else that has Dr.. ,ie as a committee member. You all should have no trouble “with it since you are _.r'ently taking undergraduate genetics! Why does meiosis I explain Mendel’s law of segregation and law of independent assortment, as well as explaining why humans have a 50:50 sex ratio? Please illustrate using one pair of autosomes and one pair of heteromorphic sex chromosomes. Use a male from a species with heterogametic males. You may annotate your drawing as necessary; be sure you define all your symbols. 14 pts. W x \i ’ X X Malt, \nuMcm six memoscmfi ix. KW auiosomt gum“ Ma'wsis - mé‘rapkmsc 1 mciUSiS‘ Nanette“ I hipwms law :38 ‘inltepenbtmi sssev’mmi’ bzcausa tack chitv‘éa lines a? fist We mt‘i-WM‘N am imbitganiimi at Hm: at‘nir were. X“ “my “X“ {gum lot m fiche SM'VIWE sidt or xi“ )0 coma be an We sum: siAe. 1¥ {vitamins *5“: My ex eu‘rfifiem“ lineman each pair lines up Tofifil’lnir 0h ’i’lni. ma’mplnase i>MH- EAC‘h (ism/mt ease rzmws one; at We Chi‘abnoSsmes ”EMF” each pair. g/ “ULMMXS \miwc 9‘ ‘ 9‘ S ‘50 5% Paint? bustier. 60”" a”? We sperm will "i D , ‘ \hflW‘fi X and 33” Xvi. me‘la t5 aduafig XX annavuxj €135. ‘/ {3“ “l . )0 6. Cynthia is crossing fruit flies for independent study. She obtains the following data for progeny from a triple heterozygote carrying three receSsive mqtant alleles: for black chitin (b), for cinnabar eyes (on), and for waxy wings (Mix): all paired With their wild type, dominant alleles. This triple heter'ozygote was testcrossed and the progeny phenotypes were: Phenotype _ Number of pro eny a cinnabar 382 El; ant,“ Waive): 19* black waxy 379 into Chm wx w): b w cinnabar Waxy 69 Big mum wxmfi 5'“ f, 1» black 67 m: cm. but...“ 1,, J an waxy 48 fibfiam wkw) t9" 5* w . _ cinnabar black 44 big nan mm b c w" _ ‘ cinnabarblackwaxy 6 U9 on an wave» 1;, c, w ”3% iwild ge - 7 _ 5 e. c...“ Wm w C+ (10+? Total 1000 jr/Ne any of the genes linked? Why do you think so (briefly)? 4 pts. Yes ‘beczawsa (sf—ht ?€ns‘i’7flw one no“? in R. i: 13/ ”+50. Wat is the genotype 0 the animal to whom the triple heterozygote was testcrossed? 5 pts. , . H) CV15“ w x w )c (fir-Np” 51 air-09419042 V‘ecegfirve) c. 0r those genes which are linked, please make a map showing both gene order and distance between genes. 10 pts. [he triple heterozygote was originally made by crossing two truebreeding lines. What were these parents’ genotypes? 10 pts. Q3 m m Wilda 1 his 0‘ C“ wfiwfi /e('/Please calculate interference. 5 pts. 5) poxs'bli Mag 054853: ‘9 E. w, c, law}, I) v5 C ‘L 5,," CJ‘ of J Tim‘s Helix ii CefFEC-L 4 4 + [‘DLCW- E! w haw merges M is: 5.. M} [9+ 1- d” . L w .. ~ *i’ + ' w 3€+W££n b ané’ a. my 41m We 92+ To c in? be ‘9 (if? +qkf+ 6+5 .pa._J—P-“‘-n--. C L) m x: [so : 133 516;“: w 190° laH°c3-r.M-—+c‘r-m (um-«4w gfiueerw c and w; you“? alas-.2 at 9.13.} €5be swarm 5+9 MM 13%.} CM [0:70 a) it: {w Cc— “-r i—w.’?ac9a,;m§5 _, 99‘“ LL ” '- CC' £55” 6M “:73“ fimnf /-ih’{\/1U~'l’if1mni 3‘. “Lila” .. "if NAiiisztiii « 7. Frank has taken to breeding Duroc-Jersey pigs to supplement his graduate student stipend. In this breed of pigs, animals with the genotype Rm 8_ are red, those with the g ‘ genotype R_ 33 or r_r S_ are sandy, and those with genotype rr 33 are white. The genes show independent assortment. In the F2 generation of a cross between genotypes RR ssandrrSS: q;3;3;i I \wa/ a. What is the phenotypic ratio of red to not—red piglets? (5 pts) M if?! h} l b. Among F2 piglets that are red, what is the preportion of Rr SS? (5 pts) {jg/q \/ c. What is this mode of inheritance called (general term)? Why do you think this IS an -. :1 example of that sort of inheritance? [iv 1?;Tiiiit‘.“1‘ " it ' ' We are we W was GM MEL-«(eyeing Caren Lei mine see (5';- Wes in mm W («,th Hoe; €§Cl>V€SSeOé 59ch (39 fine. OW ”a. bats. Though not usually considered a model species because they ,ave a long generation time, bats are of considerable interest these days because they eat tons of mosquitoes, which are vector species for manyhuman pathogens.- In order ' better, she has collected two white mutant individuals from because s e observed the parents two different islands in t ' _ and grandparents of her bats, and knows that they are from truebreeding lines; ' 5 female and one mutant is male. furthermore, one mutant i w_______——-———-' ‘_.___‘____._———-' / Kristin is going to perform a complementation test to figure out if the two ' ‘nstead are alleles from two Kristin studies / Diagram the cross, including labeling both parents and offspring, if the outcome of the cross is failure to complement. (10 pts.) /o./Di&lgram the cross, including labeling both genotypes and phenotypes of parents and offspring, if the outcome of the cross is complementation. (10 pts.) a) % T0 Val-46m a wmi’kwh-‘n‘on-Mt NW?“ NW“ firgf was; MM, Z muXan-‘r‘s Mil/v3 “‘1‘ amwlfl'wf. his so“ 9“”) Wt N W nah—MK all obhih £‘l_ Wham-4’3 les 4r: prawn-ti pm, l‘ilk/M m‘t kém M Wm 4““ «Hi We Natal-:1 W W Whh‘f’w an arm 5am 3am. ‘ “(MR K wink _. (A an Bl?) " RAB» ail.w§u’%?t 615 4’3 4.3 dB 4/ inéiviémh ,9 Tim “,5th of” was arm a” I inflkflrkl W“;“j 39m; 4“ harml incl; New tie/MAM PM 2 filth/3 at 2 kiwi; 6W“ NWlxéi'VlliMl) Rage”? {it WW4; pJWElL a)? tie-(2k INA—king "m mmuwi\l~wa. l 9. Which of the following statements are true for two genes that Show the maximum fre uency of recombination (50%)? ' r f W. The genes may be on different chromosomes. (5 pts) T b. The genes may be on the same chromosome, but quite far apart. (5 pts) T Jc. The genes undergo independent assortment. (5 pts) 0i 10. Considering the situation described in question %, if a gamete is chosen at random from a heterozygous female, what is the probability that it is a parental (non~ recombinant) gamete? (5 pts) 25’]. GM [3&th t 25/ 9w pom MW 2 183'}. mt it ”if" NWT“ gay/Mia 1. Manx cats have either no tail or extremely stubby tails1 They come in all kinds of floolors. Krista thinks these animals are quite cute and has been poring War the studbooks of Manx breeders in between publishing her Scientific papers. She notes certain peculiarities in the studbooks: first that Manx breeders never breed two Manxs together, despite the popularity of the breed (and hence the ready market for Manx kittens) and second that a Manx crossed to a true-breeding non-Manx, long tailed animal generally produces 50% Manx, 50% non-Manx progeny. a. Piease describe the mode of inheritance for the Manx tailless trait, including an explanation of why breeders avoid crossing Manx animals together. (10 pts) b. if an inexperienced person did breed two Manx cats together, what would be the expected phenotypic and genotypic ratios of Manx to long tailed animals, given your reasoning above? (5 pts) 49... Moms: Mltaeé wt is imam Wm m thmgwé it‘wm as (1,311“ Mew- M mefifim Nasser” :5 tettwl » {"iettmw scams .14; two Meow “twist; 12. Answer the following questions about this pedigree. , a. What is the mode of inheritance, and why (you may use a Punnett square as your ; explanation; please be brief)? 5 pts. 0 b. What is the probability that the mating between individuals N3 and lV4 will produce an affected son? Show all your work. 10 pts. ...
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