ch2-1F110 - Chapter 2 Drug Discovery, Design and...

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Chapter 2 Drug Discovery, Design and Development
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1. Drug Discovery Before 19th century, drugs were mainly herbs and potions. Mid-19th century, scientists attempted to isolate and purify active components Today, we have a better understanding of the body at the cellular and molecular levels.
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A. Statistics Average time to market: 12-15 years Average cost: $600-800 million Cost to get drug on market: 1962…$4 million 1996…$350 million 2010…$1.2 billion (disputed)
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B. Choosing a disease How are target diseases chosen? Logical… Practical…
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C. Clinical Trials Before clinical trials… 1st: in vitro and in vivo testing on cell cultures or transgenic mice 2nd: test on lab animals for several months
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not scientist, on volunteers and patients. Four Phases 1) Phase I: healthy volunteers 2) Phase II: small group of patients 3) Phase III: larger group of patients *Drug can be licensed, marketed & prescribed. 4) Phase IV:
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ch2-1F110 - Chapter 2 Drug Discovery, Design and...

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