Ch2-2F11 - Chapter 2 (Cont.) Drug Discovery, Design and...

Info iconThis preview shows pages 1–7. Sign up to view the full content.

View Full Document Right Arrow Icon
Chapter 2 (Cont.) Drug Discovery, Design and Development
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
3. Lead Modifications Lead compound are modified to improve activity. A) Pharmacophore -important functional groups required for activity Pharmacodynamics -interactions of drugs with receptors (Chapter 3)
Background image of page 2
Auxophore -the rest of the molecule -not important for activity -may be necessary to hold molecule in a certain shape -may be advantageous to remove or modify
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
pharmacokinetics : the study of what the body does to a drug A D M E bsorption istribution etabolism xcretion
Background image of page 4
Drug Distribution Blood is the key!
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Drugs must be 1) water-soluble to enter bloodstream 2) fat-soluble to cross cell membranes into blood supply 3) stable in stomach acid PROBLEMS: Lipophilic drugs are taken up in fat tissue. Polar drugs are easily excreted by kidneys Anionic drugs can bind to plasma protein. Cationic drugs can bind to nucleic acids. The plasma concentration of free, unbound drug is the measure of the drug availability.
Background image of page 6
Image of page 7
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 20

Ch2-2F11 - Chapter 2 (Cont.) Drug Discovery, Design and...

This preview shows document pages 1 - 7. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online