L08 Animal Development II

L08 Animal Development II - Living Systems Lecture Dr....

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1 Living Systems Lecture Dr. Murray Thomson Animal Development II Genes and Development Totipotent Stem Cells Cloning from differentiated cells Genes
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2 Protein configuration - helix Transcription Factors Proteins that control gene expression in eveloping cells developing cells Includes family of homeodomain proteins Homeodomain – 60 amino acid sequence The homeodomain region binds to a specific DNA regulatory region, +ve or –ve control. gene promoter Homeodomain protein Basic helix- loop-helix roteins proteins bHLH family Includes MyoD protein duces Induces undifferentiated cells to become muscle cells http://www.blc.arizona.edu Transfection of Non-Muscle Cells
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3 Hox Genes Homeobox genes, remember the 60 amino acid common region Control body patterning and tissue differentiation For example mouse Hoxa-10 is needed for normal vertebral column. Pattern Formation enes in specific Genes in specific regions are expressed to form differentiated tissues Mouse embryos A) stained for Odd protein B) stained for Sox protein Eulamprus tympanum HoxA10
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L08 Animal Development II - Living Systems Lecture Dr....

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