MCDB 1b Midterm 1 Study Guide

MCDB 1b Midterm 1 Study Guide - MCDB STUDY GUIDE HORMONES:...

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MCDB STUDY GUIDE HORMONES: CHAPTER 41 Testosterone Abuse Performance inhancing steroid drug Male Secondary sex characterisitics deep voice body/facial hair increased bone/muscle mass increases risk of cancer, heart, liver, kidney disease Systems in body skin seperates outside/inside extracellular fluid bathes all cells digestive system: nutrients circulatory: moves material in body urinary: maintains water/salt balance, eliminates waste from blood cells exchange materials respiratory: supply 02 remove C02 all connected to circulatory What are hormones? chemical messages slow communication btw cells can take seconds to days long term processes
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not good for rapid actions ENDOCRINE SYSTEM Endocrine Cells secrete hormones into interstitial fluid or blood stream some single cells in a tissue EX digestive hormones form cells in wall of stomach/small intestine gastrin, secretin, choecystokinin, gastrin inhibitory peptide Exocrine Cells secrete substances into ducts to the outside world or gut Epithelial Cells line body cavities: lungs, kidney, bladder, stomach intestines line body covering: skin 60% of cells Endocrine Glands secrete hormones into blood, like capillaries near the cell, circulating released from the blood can travel long distances and effect far away cells only bind to cells with certain receptor molecules groups of endocrine cells 9 major glands in endocrine system Paracrines secreted by endocrine cells effect function of nearby cells doesn’t enter blood stream
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released in tiny amounts, inactivated rapidly by enzymes, or take up by local cells Autocrine influences the same cell that secretes them never in circulatory system released in tiny amounts, inactivated rapidly by enzymes, or take up by local cells CIRCULATING HORMONES diffuse through the blood binds to a receptor and triggers a response same hormone can cause different responses in different cells EX epinephrine (adrenaline) secreted by the adrenal glands “flight-or-fight” response heart beats faster/stronger fatty acid for fuel from fat cells to the blood; another energy source blood vessels to stomach, skin constrict so more blood to muscles liver breaks down glycogen-->glucose for fuel to blood, quick energy HOW IT BINDS WITH G PROTEINS?????? Groups of Proteins: 1. Peptides/Proteins water soluble transported out of the cell (exocytosis) that made them by vesicles receptors on the surface of target cells because polar and cannot diffuse through membrane no carrier proteins EX: growth hormone, insulin
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2. Steroid Hormones lipid soluble and membrane permeable diffuse in and out of cell that made them need carrier proteins in blood receptors in the cell (nucleus or cytoplasm) because non-polar and can diffuse through made from cholesterol EX: Estrogen 3. Amine Hormone derivative of amino acid tyrosine some water/some lipid soluable different release methods RECEPTORS Receptors for Water-Soluble Proteins large glycoproteins on cell surface 3 parts: binding domain: projecting outside membrane
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This note was uploaded on 10/18/2011 for the course MCDB 1B taught by Professor Weimbs during the Winter '08 term at UCSB.

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MCDB 1b Midterm 1 Study Guide - MCDB STUDY GUIDE HORMONES:...

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