BMB 401 Exam 2 Study Guide

BMB 401 Exam 2 Study Guide - Rate limiting step= takes...

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21:51 LECTURE 11 Heme Synthesis Formation of Protoporphyrin IX Asymmetric ring structure Chelation of Iron Formation of Heme Requires: 4 Mitochondrial enzymes 4 Cytosolic enzymes Begins in mitochondrial matrix   continues in cytosol   ends back in mitochondrion Heme Biosynthesis:  Making Protophorphyrin IX Reaction 1: Condensation reaction between Succinyl CoA and Glycine to form  - Aminolevulinate δ Succinyl CoA- activated form of succinate Enzyme:   – Aminolevulinate Synthase δ Place: Mitochondrial Matrix
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Heme synthesis: Regulation Reaction 1:  - ALA synthase δ First and rate limiting step : (in mitochondrial matrix)
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Unformatted text preview: Rate limiting step= takes longest time & dictates pathway speed. . generally most regulated step Regulation: primarily by negative feedback 1. Transport of ALA synthase into the mt blocked by high heme concentration Heme negative feedback effect on: 2. Transcription 3. mRNA stability 4. Translation Reaction 2: Dehydration Synthesis 1. ALA transport to cytosol 2. 2 molecules of ALA form each porphobilinogen molecule 8 ALA = 4 porphobilinogen 2. Translation: negative feedback by heme reduces translation ALA mRNA LECTURE 14 VITAMIN COENZYME 21:51 21:51...
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This note was uploaded on 10/18/2011 for the course BMB 401 taught by Professor Kaguni during the Fall '08 term at Michigan State University.

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BMB 401 Exam 2 Study Guide - Rate limiting step= takes...

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