Ch17 - Ch 17 From a Gene to a Protein Prolog or overview....

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Ch 17 From a Gene to a Protein Prolog or overview. What is a mutation and what makes it harmful or beneficial? Gene expression is the process by which DNA directs the synthesis of proteins and RNA’s 1. Genes encode for proteins a. The Story i. Archibald Garrod suggest that genes dictate phenotypes through enzymes 1. studies inborn errors of metabolism 2. Linked biochemistry and genetics ii. Nutritional mutants (studies by Beadle and Tatum) 1. Neurospora a bread mold 2. Treat with ionizing X rays that make mutations 3. Growth on Minimal medium a. Only sugars and salts that support slow growth i. Catabolism breaks down sugar and gives energy ii. Anabolism makes the materials for cell growth b. Mutations in either will prevent growth 4. Complete growth medium has all 20 aa supplemented 5. pathway precursor, ornithine, citrulline argine One of the first pathways studied genetically. iii. While proteins are the focus of these studies, we see that other items like RNA are also the product of genes.
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This note was uploaded on 10/19/2011 for the course BIOL 230 taught by Professor Case,c during the Spring '08 term at Skyline College.

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Ch17 - Ch 17 From a Gene to a Protein Prolog or overview....

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