ch 16 dna - Ch 16 The Molecular Basis of Inheritance. 1....

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Ch 16 The Molecular Basis of Inheritance. 1. DNA is the material of Genetics a. The story of the search for genetic material. i. What molecules held Genetic information ii. The case for proteins was strong because of the heterogeneity. iii. Finally the proper experimental organism was found 1. Streptococcus pneumoniae a. Frederick Griffith b. Worked with 2 forms of bacteria i. Pathogenic ii. Nonpathogenic c. When killed pathogenic strains were mixed with nonpathogenic, some of the nonpathogenic became pathogenic. Called transformation. d. Avery, McCarthy and MacLeod purified portions of the pathogenic strain and determined that the transforming principle was DNA this was greeted with skepticism. 2. Bacteriophage T2 a. This organism consists of protein and DNA nothing else. What does the control. b. Hershey and Chase used radioactive isotopes i. Sulfur only in protein ii. Phosphorus only in DNA c. Showed that only DNA entered the cell. 3. Additional Evidence a. Erwin Chargaff b. DNA consists of i. Nitrogenous base ii. Pentose sugar iii. Phosphate group c. 1950’s announced that different organisms had different nitrogenous base ratios. i.
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ch 16 dna - Ch 16 The Molecular Basis of Inheritance. 1....

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