ch08_review - Klug, Concepts of Genetics 8/e Chapter 8...

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Klug, Concepts of Genetics 8/e Chapter 8 MEDIA REVIEW QUESTIONS 1. What is the general term for a condition in which the chromosome number is not a multiple of a complete set? a. Triploidy b.Aneuploidy c. Polyploidy d.Trisomy 2. Which gametes will be produced if nondisjunction occurs during the second meiotic division? a. All trisomic gametes b.All haploid gametes c. Two diploid gametes and two haploid gametes d.Two haploid gametes, one diploid gamete, and one gamete missing a copy of one of the chromosomes 3. What is the specific term that describes the loss of a single chromosome (2 n – 1)? a. Monosomy b.Trisomy c. Monoploidy d.Aneuploidy 4. Which of the following human genetic diseases is caused by a partial monosomy? a. Edwards syndrome b.Fragile X syndrome c. Cri-du-chat syndrome d.Turner syndrome 5. Which genetic disease is caused by a trisomy for chromosome 13? a. Edwards syndrome b.Patau syndrome c. Cri-du-chat syndrome d.Down syndrome 6. Which human chromosomes have been observed in an aneuploid condition in fetuses? a. X, Y, and chromosome 21 b.Chromosomes 21, 18, and 13 c. Only the sex chromosomes X and Y d.All chromosomes 7. Which term specifically refers to the gain of extra chromosome sets from individuals of the same species? a. Triploidy b.Euploidy c. Autopolyploidy d.Allopolyploidy 8. Chromosomal aberrations may be characterized by all of the following except a. Frameshift mutations b.Chromosome loss c. Inversions d.Translocations 9. The hypothesis that gene duplication is essential to evolution is supported by the existence of a. Gene families
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b.Intercalary deletions c. Inversions d.Fragile sites 10. What distinguishes paracentric inversions from pericentric inversions? a. The formation of dicentric bridges b.The number of centromeres involved in the inversion c. One suppresses crossovers, the other encourages crossovers d.The placement of the centromere in the inversion 11. Why would the transmission of Down syndrome resulting from a Robertsonian translocation be unaffected by the age of the mother? a. Mothers with a Robertsonian translocation never have children. b.This statement is incorrect; the age of the mother does affect the transmission of Down syndrome resulting from Robertsonian translocations. c. Robertsonian translocations occur only in young mothers. d.Down syndrome resulting from a Robertsonian translocation does not result from nondisjunction, which is affected by age. 12. True or false? Fragile-X syndrome is thought to be caused by the inactivation of a gene spanning the fragile region on the X chromosome due to a large number of trinucleotide repeats just upstream from the coding sequence of the gene. 13. Which of the following statements about nondisjunction is false? a. It occurs more frequently in human females over age 35.
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ch08_review - Klug, Concepts of Genetics 8/e Chapter 8...

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