ch11_review - Klug, Concepts of Genetics 8/e Chapter 11...

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Klug, Concepts of Genetics 8/e Chapter 11 MEDIA REVIEW QUESTIONS 1. In the Meselson-Stahl experiment, which mode of replication was eliminated based on data derived after one generation of replication? a. Dispersive b. Semiconservative c. Conservative d. None of the modes 2. Which DNA polymerase is mainly responsible for genome replication in E. coli ? a. DNA polymerase III b. DNA polymerase α c. DNA polymerase I d. DNA polymerase II 3. Which of the following molecules is not required for the synthesis of DNA in vitro by DNA polymerase? a. ATP b. Template c. Deoxynucleoside triphosphates d. Primer 4. Which enzyme in E. coli is responsible for relieving the tension ahead of the fork that results when the DNA is unwound to form the replication bubble or eye? a. Replicase b. Helicase c. DNase d. Gyrase 5. Why is an RNA primer considered essential for DNA synthesis by DNA polymerase III? a. There is no particular reason; that is simply what has been observed. b. The enzyme requires a free 3'-OH group. c. The enzyme requires a free 3'-PO 4 group. d. The enzyme requires a free 5'-PO 4 group. 6. Which of the following statements best describes Okazaki fragments? a. They are formed in the leading strand. b. They add nucleotides to the elongating DNA. c. They are formed in the lagging strand. d. They are synthesized by primase. 7. Which enzyme or enzymatic activity is not involved in resolution of the Okazaki fragments in E. coli ? a. DNA ligase b. 5' to 3' exonuclease activity of DNA polymerase I c. RNA ligase d. 5' to 3' polymerase activity of DNA polymerase I 8. Which activity of E. coli DNA polymerase I is responsible for proofreading the newly synthesized DNA? a. 5' to 3' polymerase b. 3' to 5' endonuclease c. 3' to 5' exonuclease d. 5' to 3' exonuclease
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9. All of the following are differences between eukaryotic and prokaryotic DNA replication except a. The type and number of polymerases involved in DNA synthesis b. The number of replication origins c. The rate of DNA synthesis d. The ability to form a replication fork 10. Which of the following characteristics cannot be attributed to telomeres? a. Telomerase enzyme b. Formation of hairpin loops c. Links to the aging process d. Found in eukaryotes and prokaryotes 11. Which term describes a genetic exchange between two DNA molecules with substantial DNA sequence homology? a. Homologous recombination b. Somatic recombination c. Illegitimate recombination d. Site-specific recombination 12. Which event is the consequence of a mismatch in the heteroduplex that forms during general recombination? a. Strand invasion b. Holliday structure formation c. Gene conversion d. Branch migration 13. Which of the following statements about DNA replication is true?
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ch11_review - Klug, Concepts of Genetics 8/e Chapter 11...

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