D3 - Bio 311D Introductory Biology II Discussion#3 Todays...

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Today’s topics More Genetics (abnormal chromosomes) Population Genetics Evolution Quiz 2 (memorization test) Bio 311D: Introductory Biology II Discussion #3
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Review Session for Exam #1 Thursday Sep 22th 5pm-6:30pm, RLM 4.102 Attendance is optional
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6. Assuming an unknown disease affected by one gene, in a family, both parents are heterozygous on this gene but not affected by the disease. They have 10 children (5 sons, 5 daughters). All the boys show the disease symptom in early age. The most likely inheritance pattern of this disease gene is: A. Autosomal dominant B. Autosomal recessive C. Sex-linked dominant D. Sex-linked recessive Quiz 1 Multiple Choice #6
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Changes in Chromosome Structure
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Aneuploid : a few chromosomes change (result from unequal segregation during meiosis) Sex chromosome changes i.e. XXY Autosome changes i.e. 3 Chromosome #21 (Down syndrome) Polyploid : whole set of chromosomes get changed (duplicated) i.e. 3n (69 chromosomes in human), 4n , …… Infertility . Seedless watermelon is a polyploid (3n) Changes in Chromosome Number
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Disease Abnormal chromosome Total #Chromos omes Gender affected Symptom Changes in number of Sex chromosomes Klincfelter syndrome XXY 2n = 47 Male Speck syndrome XYY 2n = 47 Male Turner syndrome X 2n = 45 Female Trisomy X XXX 2n = 47 Female Changes in number of autosomes Down Syndrome (Trisomy 21) 3 copies of Chr #21 2n = 47 Male or female
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Dosage compensation Genetic regulatory mechanism which operates to equalize the phenotypic expression of characteristics determined by genes on the X chromosome so that they are equally expressed in the human XY male and the XX female.
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