Gallouzi 454 Sept 12 2011

Gallouzi 454 Sept 12 2011 - Model for the Export of 60S...

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Model for the Export of 60S Ribosome Subunit
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- One major difference between transport of mRNP and RNPs (karyopherin-mediated transport) through the NPC is the size of the cargo. - In fact, an mRNA associated with its mRNPs proteins could have a mass of, in some cases, > 50 MD (mega dalton).
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Nuclear Export of mRNA - mRNAs export occurs only following the attachment of the m 7 G cap at the 5 end. Splicing , polyA addition and the attachment of various proteins takes place during these steps . - Export requires the function of adaptor proteins that couple the mRNA to the exportin complex. - In general, it is believed that Ran-GTP is not involved (unlike the export of other RNAs). - Certain viral RNAs contain a constitutive transport element (CTE) that eliminates the need for an adaptor protein.
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Nuclear export of cellular mRNPs is highly selective Only fully processed RNAs are normally exported Incompletely spliced precursor mRNAs (pre-mRNAs) and excised introns are actively retained within the nucleus Several proteins associated with the mRNP in the nucleus are selectively
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