ch18_review - Klug, Concepts of Genetics 8/e Chapter 18...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
Klug, Concepts of Genetics 8/e Chapter 18 MEDIA REVIEW QUESTIONS 1. Cancer is best described as a. A genetic disorder at the cellular level b. A genetic disease at the somatic cell level c.A genetic disease at the gametic cell level d. A bacterial disease at the somatic cell level  2. Mutations in two genes,  hMSH 2 and  hMLH 1, have been shown to be involved in  the development of hereditary colorectal cancer. What is the role of these two  genes? a. They are both tumor suppressors. b. They are involved in mismatch DNA repair. c.They prevent cells from exiting the cell cycle and undergoing apoptosis. d. They are both proto-oncogenes. 3. Why are cyclins expressed at different times and at different levels during the cell  cycle? a. Cyclins are involved in arresting the cell cycle. Removal of certain cyclins  allows the cell cycle to proceed. b. Cyclins are transcription factors responsible for the expression of crucial cell- cycle proteins. c.Different cyclins combine with protein kinases at different stages of the cell cycle  to affect the cell cycle. d. One or more cyclins must interact with each other to control the cell cycle. 4. What is the role of the cyclinB/CDK1 complex? a. It is involved in the phosphorylation of various proteins to allow the transition  from G1 into S. b. It is involved in the dephosphorylation of various proteins to allow the transition  from G2 into M. c.It is involved in arresting the cell at the G2/M transition until the proper signals  are received. d. It is involved in the phosphorylation of various proteins to allow the transition  from G2 into M. 5. True or false? Apoptosis represents genetically programmed cell death.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
6. What is the relationship between proto-oncogenes and oncogenes? a. Oncogenes are versions of proto-oncogenes that have been permanently  switched off. b. Oncogenes are mutant forms of proto-oncogenes. c.Both are involved in arresting the cell cycle. d. Both must be activated to halt cell division. 7. The function of the  ras  gene family involves a. Signal transduction b. Tumor suppression c.Chromosome segregation d. Chromatin condensation 8. What is the role of the p53 protein in the cell cycle in normal cells? a. It causes cells to enter G0 and stop dividing. b. It binds to cyclin-dependent kinases to selectively phosphorylate certain  proteins. c.It temporarily arrests the cell cycle in G1 before entering S. d.
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This test prep was uploaded on 04/06/2008 for the course BIOL 313 taught by Professor Vollbrecht during the Spring '08 term at Iowa State.

Page1 / 11

ch18_review - Klug, Concepts of Genetics 8/e Chapter 18...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online