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3 Development 2 Stem Cells

3 Development 2 Stem Cells - from NIH’s “Stem Cell...

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New Applications and Recent Research in Developmental Biology: Is Cellular Differentiation Reversible? • Evidence from Cloning Animals • Evidence from Stem Cell Research
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Fig. 20-20 Cultured stem cells Early human embryo at blastocyst stage (mammalian equiva- lent of blastula) Different culture conditions Different types of differentiated cells Blood cells Nerve cells Liver cells Cells generating all embryonic cell types Adult stem cells Cells generating some cell types Embryonic stem cells From bone marrow in this example Stem Cells
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From: Yu and Thompson (2004) “Embryonic Stem Cells” from NIH’s “Stem Cell Information Center” at: http://stemcells.nih.gov/info/scireport/ Embryonic Stem Cells are Pluripotent
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Adult Stem Cells from Bone Marrow are Multipotent From: Domen, Wagers, and Weissman (2004), “Bone Marrow (Hematopoietic) Stem Cells”
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Unformatted text preview: from NIH’s “Stem Cell Information Center” at: http://stemcells.nih.gov/info/scireport/ From: Battey et al. (2008), “Alternate Methods for preparing pluripotent stem cells”, from NIH’s “Stem Cell Information Center” at: http://stemcells.nih.gov/info/scireport/ From: Battey et al. (2008) “Alternate Methods for preparing pluripotent stem cells”, from NIH’s “Stem Cell Information Center” at: http://stemcells.nih.gov/info/scireport/ A Third Method of Deriving Pluripotent Stem Cells! Science Magazine’s “Breakthrough of the Year”, 2008: Reprogramming Cells Four Experimental Routes for Nuclear Reprogramming From: Gurdon and Melton (2008) “Nuclear Reprogramming of Cells”, Science Vol 322, 1811-1815....
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