6 Muscle 3 Skeletal Muscle

6 Muscle 3 Skeletal Muscle - Muscle I. Overview of the...

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Unformatted text preview: Muscle I. Overview of the vertebrate nervous system II. Types of Muscle - smooth, cardiac and skeletal III. Skeletal Muscle A. Structure B. Contraction - the sliding filament theory C. Crossbridge cycling D. The neuromuscular junction E. Excitation-Contraction Coupling Fig. 50.25 Skeletal Muscle Structure Bundle of muscle fibers TEM Muscle Thick filaments (myosin) M line Single muscle fiber (cell) Nuclei Z lines Plasma membrane Myofibril Sarcomere Z line Z line Thin filaments (actin) Sarcomere 0.5 m Thin Filament Two strands of actin filament and one strand of regulatory proteins including tropomyosin and troponin complex that plays a role in regulating contraction Actin Tropomyosin Ca 2+-binding sites Troponin complex (a) Myosin-binding sites blocked Myosin in Thick Filament Myosin II (conventional) : Globular head (motor) Neck binds 2 light chains Coiled coil rod mediates dimerization Thick Filament made of Myosin Fig. 50.26 Z Relaxed muscle M Z Fully contracted muscle Contracting muscle Sarcomere 0.5 m Contracted Sarcomere The Sliding-filament Model of Muscle Contraction The Sliding-filament Model of Muscle Contraction Fig. 50.27Fig....
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This note was uploaded on 10/21/2011 for the course BIO 102 taught by Professor Robinson during the Spring '09 term at UPenn.

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6 Muscle 3 Skeletal Muscle - Muscle I. Overview of the...

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