ch20_review - Klug Concepts of Genetics 8/e Chapter 20...

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Klug, Concepts of Genetics 8/e Chapter 20 MEDIA REVIEW QUESTIONS 1. How does shotgun cloning differ from the clone-by-clone method? a. The location of the clone being sequenced is known relative to other clones  within the genomic library in shotgun cloning. b. The entire genome is sequenced in the clone-by-clone method, but not in  shotgun sequencing. c.No genetic or physical maps of the genome are needed to begin shotgun cloning. d. Computer software assembles the clones in the clone-by-clone method. 2. CpG islands and codon bias are tools used in eukaryotic genomics to a. Identify open reading frames b. Differentiate between eukaryotic and prokaryotic DNA sequences c.Find regulatory sequences d. Look for DNA-binding domains 3. Which of the following statements about bacterial genomes is false? a. There is some overlap in size between bacterial and eukaryotic genomes. b. Plasmids can be transferred between unrelated species of bacteria. c.Overlapping genes are very common. d. Introns are extremely rare. 4. Which of the following elements is  not  found in most eukaryotic genomes? a. Introns b. Operons c.Repetitive sequences d. Low gene density 5. What is a characteristic of the human genome? a. A majority of genes of unknown function b. Almost no duplicated regions c.Larger and more intron-rich genes than invertebrates d. Uniform distribution of genes along chromosome arms 6. Obstacles to completion of the human genome include all of the following  except a. Repetitive regions of DNA b. Accurate predictions of genes c.The difficulty of cloning and sequencing heterochromatic DNA
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d. The presence of pseudogenes 7. True or false? The study of orthologs would be useful to determine the function of a  specific gene in a species. 8. Gene duplication has been found to be one of the major reasons for genome  expansion in eukaryotes. What is the selective advantage of gene duplication? a. Gene duplication leads to new species evolution. b. If one gene copy is nonfunctional, a backup is available. c.Larger genomes are more resistant to spontaneous mutations. d. Duplicated genes make more of the protein product. 9. Globin superfamily diversity arose primarily from a. Gene duplication and divergence b. Alternative exon splicing c.Developmentally timed expression d. Posttranslational modification 10. Which technique would be employed if a proteomics approach were used to find  the cause of a muscle disorder? a.
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This test prep was uploaded on 04/06/2008 for the course BIOL 313 taught by Professor Vollbrecht during the Spring '08 term at Iowa State.

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ch20_review - Klug Concepts of Genetics 8/e Chapter 20...

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