lecture23_slides

lecture23_slides - Overview of today Today Quick review of...

Info iconThis preview shows pages 1–6. Sign up to view the full content.

View Full Document Right Arrow Icon
Overview of today Today: Quick review of k-means clustering More on clustering: - Validating clusters - Midterm #2 review
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Hierarchical vs. k-means clustering Samples Hierarchical: K-means:
Background image of page 2
Method #2: K-means clustering • 1. Define k = number of clusters • 2. Randomly initialize a seed vector for each cluster (could use a random gene vector) • 3. Go through all genes, and assign each gene to the cluster which it is most similar to • 4. Recalculate all seed vectors as means (or medians) of patterns of each cluster • Repeat 3&4 until <stop condition>
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
How do we validate clustering results? • Biological validation (like we saw last time) • Systematic comparison with established knowledge of gene function – Where can we get “established” knowledge of gene function? Answer: standardized gene function classification schemes
Background image of page 4
The Gene Ontology: a standardized basis for classifying function What is GO? “GO (Gene Ontology) is a controlled vocabulary used to describe the biology of a
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 6
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 10/21/2011 for the course CSCI 3003 taught by Professor Staff during the Spring '08 term at Minnesota.

Page1 / 20

lecture23_slides - Overview of today Today Quick review of...

This preview shows document pages 1 - 6. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online