Toxins+Lecture - Chemical and Biological Weapons Toxins...

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Michael P. Shakarjian, Chemical and Biological Weapons Toxins
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Michael P. Shakarjian, Toxins Botulinum Ricin Tricothecene Aflatoxin Ergot Alkaloids Saxitoxin Staph Enterotoxin B
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Michael P. Shakarjian, What is a toxin? Toxin vs. Poison? Protein or Small molecules Not man made (as compared with “chemical agents.”) Not living Biological toxins are poisonous substances that are produced by a variety of living organisms such as: Fungi - Flowering Plants Bacteria - Animals Some of the most poisonous substances known. Tend to be more toxic per weight than many chemical agents. Purpose: Predation (spider, snake, scorpion, jellyfish, wasp, snail) Defense (bee, poison dart frog, deadly nightshade, honeybee, wasp)
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Michael P. Shakarjian, History: Poisons and Toxicology Mithridates VI (Eupater, the great) 132-63 BC Mithra – god of light (the sun is the eye of mithra) One of Rome’s greatest enemies Persian King Succeeded father at age 11 Courage, Bodily strength and size Skill in the use of weapons, riding, and in the chase Speed of foot Capacity for eating and drinking Penetrating intellect Mastery of 22 languages He united subtlety, superstition, and obstinate endurance of an oriental.
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Michael P. Shakarjian, Pontus
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Michael P. Shakarjian, Mithridates VI (Cont.) Collected curiosities and works of art Assembled Greek men of letters round him Gave prizes to the greatest poets and best eaters. Spent much of his time in practicing magic and it was believed that he had so saturated is body with poisons that none could injure him. He trusted no one Murdered his mother, his sons, the sister whom he married. To prevent his harem from falling to his enemies, he murdered his concubines, and his followers were never safe. Vainly tried to poison himself when his own troops, led by his son, revolted.
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Michael P. Shakarjian, Paracelsus – A Father of Toxicology 1493-1541 Knowledgeable of alchemy by age 16 -Studied also astrology, surgery and medicine -Introduced the use of opium and mercury -Knowledgeable of the science and principles of magnetism Traveled extensively, gathering information Unconventional upstart Miracle worker Considered a heretic "the precursor of chemical pharmacology and therapeutics and the most original medical thinker of the sixteenth century." Auroleus Phillipus Theostratus Bombastus von Hohenheim "All things are poisons, for there is nothing without poisonous qualities. ..it is only the dose which makes a thing poison."
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Michael P. Shakarjian, Poisons and Society Long been public fear and antipathy towards the use of poison Dread factor Heightened anxiousness Panic Hysteria Ex.: Sarin – 5,500 people went to the hospital (Killed 12, seriously injured 54, affected 980 more)
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Michael P. Shakarjian, Botulinum Toxin BOTOX Source: Clostridium botulinum
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This note was uploaded on 10/23/2011 for the course PUBLIC POL 090 taught by Professor Rossi during the Spring '11 term at Rutgers.

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Toxins+Lecture - Chemical and Biological Weapons Toxins...

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